Regioselective O-demethylation of aporphines with methanesulfonic acid/methionine: An efficient one-pot transformation of thebaine to (R)(-)-2-methoxyapomorphine

Article abstract of DOI:10.1080/00397919508011359

2-Methoxyapomorphine (4) was obtained by the rearrangement of thebaine (1) with methanesulfonic acid in the presence of methionine, a reagent system suitable for the regioselective O-demethylation of aporphine derivatives.

Full text of DOI:10.1080/00397919508011359

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Synthetic Communications: An
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Organic Chemistry
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Regioselective O-
Demethylation of Aporphines
with Methanesulfonic Acid /
Methionine: An Efficient
One-Pot Transformation
of Thebaine to (R)(-)-2-
Methoxyapomorphine
a
a
a
S. Berényi , C. Csutorás , S. Gyulai & S. Makleit
a
a
Department of Organic Chemistry , Lajos Kossuth
University , P.O. Box 20, Debrecen, H-4010, Hungary
Published online: 23 Sep 2006.
To cite this article: S. Berényi , C. Csutorás , S. Gyulai & S. Makleit (1995)
Regioselective O-Demethylation of Aporphines with Methanesulfonic Acid /
Methionine: An Efficient One-Pot Transformation of Thebaine to (R)(-)-2-
Methoxyapomorphine, Synthetic Communications: An International Journal
for Rapid Communication of Synthetic Organic Chemistry, 25:3, 283-288, DOI:
10.1080/00397919508011359
To link to this article: http://dx.doi.org/10.1080/00397919508011359
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