Journal of the Chemical Society. Perkin transactions I p. 1383 - 1389 (1991)
Update date:2022-08-11
Topics:
Anwar, Saeed
Bradley, Gavin
Davis, Anthony P.
The role of 1,2-asymmetric induction has been investigated in the 1,3-anti-selective reduction of β-hydroxy ketones via intramolecular hydrosilylation.For the α-methyl β-hydroxy ketones 2a, 3a, the effect of the α-substituent is negligible except that it appears to reinforce 1,3-asymmetric induction.For the α-ethyl β-hydroxy ketones 2b, 3b, 1,3-asymmetric induction is dominant but not overwhelming.The super-acid TfOH2(1+) B(OTf)4(1-) has been used as a catalyst for the hydrosilylation giving, in one case, an improved result when compared with previous methodology.
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