Journal of Materials Chemistry B p. 4428 - 4433 (2020)
Update date:2022-08-11
Topics:
Hu, Lianzhe
Hu, Xilu
Huang, Ting
Liao, Hong
Wang, Min
In this study, the phosphatase mimetic activity of zirconium oxide nanoparticles (ZrO2NPs) has been demonstrated. They can effectively catalyze the dephosphorylation of a series of commercial fluorogenic and chromogenic substrates of natural phosphatases. Compared with natural phosphatases, ZrO2NPs possess several advantages such as low cost, facile preparation procedures, and high stability in a broader pH range or at high temperatures. In addition, the activity of ZrO2NPs toward some important biomolecules was investigated. The ZrO2NPs can catalyze the dephosphorylation of ATP ando-phospho-l-tyrosine, but they cannot react with DNA strands. These data are important for the further bio-related applications of ZrO2NPs. Finally, the potential application of ZrO2NPs in intracellular imaging is also demonstrated by using a near-infrared fluorescent substrate of alkaline phosphatase.
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