A reproducible and high-yielding cerium-mediated route to α,α-difluoro-β-ketophosphonates

Article abstract of DOI:10.1016/S0040-4020(97)00673-X

The addition of diethyldifluoromethylphosphonate to LDA containing cerium(III) chloride in THF generates an organometallic nucleophile that reacts efficiently with esters and DMF (1,2-addition) affording moderate to good yields of adducts, and extending considerably the range of compounds available containing the difluoromethylenephosphonate group.