Synthesis of methyl (5Z,8Z,11Z,14Z,17E)-eicosapentaenoate and methyl (4Z,7Z,10Z,13Z,16Z,19E)-docosahexaenoate

Article abstract of DOI:10.1016/0009-3084(94)90059-0

(3Z,6Z,9Z,12E)-Pentadecatetraenal, a common intermediate in the synthesis of methyl Δ17t EPA and methyl Δ19t DHA, was obtained by copper(I)-catalyzed coupling between the Grignard reagent of 1,1-diethoxy-3-butyne and (Z,E)-1-bromo-5,8-undecadien-2-yne fol