M. L. Salum, R. H. de Rossi, E. I. Buján
FULL PAPER
carried out in two flasks, one containing 3 (7ϫ10–5 ) in 1,4-diox-
ane and the other the rest of the constituents of the reaction mix-
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ture; both solutions were mixed under positive N
2
pressure.
1
[
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For the reaction of 3 in 60% 1,4-dioxane/H O at reflux under N
2
8]
2
the method previously described was used;[ 3 (3.5ϫ10 ) and
NaOH (0.14 ) were refluxed until no substrate was detected by
TLC. The reaction products 4 and 5 were isolated by column
chromatography on silica gel by eluting with variable amounts of
hexane/EtOAc and were identified by TLC by comparison with an
authentic sample.
–3
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Acknowledgments
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This research was supported by the Consejo Nacional de Investiga-
ciones Científicas y Técnicas, Argentina (CONICET), the Agencia
Nacional de Promoción Científica y Tecnológica (FONCYT) and
the Secretaría de Ciencia y Tecnología, Universidad Nacional de
Córdoba, Argentina. M. L. S. is a grateful recipient of a fellowship
from CONICET.
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= 1, 2, 3 and 4 –1 are K =
–1
–1
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.6, 1.9, 2.3 and 2.6 and K
respectively.
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= 4.7, 6.0, 7.0 and 8.0 ,
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Received: October 5, 2006
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Published Online: March 14, 2007
2174
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