Synthesis and Anticholinergic Activity of the Four Stereoisomers of 4-(Dimethylamino)-2-phenyl-2-(2-pyridyl)pentanamide

DOI: 10.1021/jm00035a019

Source and publish data:

Journal of Medicinal Chemistry p. 1378 - 1381 (1994)

Update date:2022-08-11

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Authors:

Oyasu, Hitoshi

Nagano, Masanobu

Akahane, Atsushi

Tomoi, Masaaki

Tada, Toshiji

Matsuo, Masaaki

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Article abstract of DOI:10.1021/jm00035a019

The four stereoisomers of 4-(dimethylamino)-2-phenyl-2-(2-pyridyl)pentanamide were synthesized, and the absolute configuration were determined by X-ray crystallography.Pharmacological testing for anticholinergic activity revealed great differences in pote

Full text of DOI:10.1021/jm00035a019

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