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| CAS No.: | 121-24-4 |
|---|---|
| Name: | GSSG |
| Molecular Structure: | |
|
|
|
| Formula: | C20H32N6O12S2 |
| Molecular Weight: | 612.639 |
| Synonyms: | L-GLUTATHIONE OXIDISED;L-GLUTATHIONE OXIDIZED;L-GLUTATHIONE (OXIDIZED FORM);CYCLIC(GAMMA-GLU-CYS-GLY);CYCLIC(GAMMA-GLU-CYS-GLY)2;GSSC;GSSG;(-)-GLUTATHIONE, OXIDIZED |
| EINECS: | 248-170-7 |
| Melting Point: | 178 °C (dec.)(lit.) |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | R36/37/38 |
| PSA: | 368.24000 |
| LogP: | -0.91260 |
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Chemistry
Chemical Name: GSSG
IUPAC NAME: 2-amino-5-[[3-[2-[(4-amino-5-hydroxy-5-oxopentanoyl)amino]-3-(carboxymethylamino)-3-oxopropyl]disulfanyl-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
CAS No.: 121-24-4
EINECS: 248-170-7
RTECS: MC0556500
Molecular Formula: C20H32N6O12S2
Molecular Weight: 612.63 g/mol
Melting Point: 178 °C (dec.)(lit.)
Density: 1.54 g/cm3
Flash Point: 677.4 °C
Boiling Point: 1196.5 °C at 760 mmHg
Storage temp.: 2-8°C
Following is the structure of GSSG (CAS No.:121-24-4):
Product Categories about GSSG (CAS No.:121-24-4) is refer to Sulphur Derivatives
The chemical synonymous of GSSG (CAS No.:121-24-4) are L-Glutathione oxidised ; L-Glutathione (OXIDIZED FOrm) ; Cyclic(Gamma-Glu-Cys-Gly) ; Cyclic(Gamma-Glu-Cys-Gly)2 ; GSSC ; GSSG ; (-)-Glutathione, oxidized
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intravenous | > 2gm/kg (2000mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 6793, 1989. | |
| mouse | LD50 | oral | > 5gm/kg (5000mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 6793, 1989. | |
| mouse | LD50 | subcutaneous | > 2gm/kg (2000mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 6793, 1989. | |
| rat | LD50 | intravenous | > 2gm/kg (2000mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 6793, 1989. | |
| rat | LD50 | oral | > 5gm/kg (5000mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 6793, 1989. | |
| rat | LD50 | subcutaneous | > 2gm/kg (2000mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 6793, 1989. |
Safety Profile
Hazard Codes: 
Xi
Risk Statements about GSSG (CAS No.:121-24-4):
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements about GSSG (CAS No.:121-24-4):
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
Specification
GSSG (CAS No.:121-24-4) is a disulfide derived from two glutathione molecules.In living cells, glutathione disulfide is reduced into two molecules of glutathione with NADPH/H+ (Niacin Analog) catalyzed by the enzyme glutathione reductase. Antioxidant enzymes, such as glutathione peroxidases and glutaredoxins, generate glutathione disulfide during the reduction of hydroperoxides (RO-OH):
2GluSH + RO-OH → GluS-SGlu + ROH + H2O