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| CAS No.: | 357-70-0 |
|---|---|
| Name: | Galanthamine |
| Molecular Structure: | |
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| Formula: | C17H21NO3 |
| Molecular Weight: | 287.359 |
| Synonyms: | 6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol,4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl- (7CI);Galanthamine (6CI,8CI);(-)-Galantamine;(-)-Galanthamine;6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol,4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, [4aS-(4aa,6b,8aR*)]-;BRN 0093736;Galantamin;Galantamina;Jilkon;Lycoremin;Lycoremine;NSC 100058;(+)Galanthamine;736-79-8; |
| EINECS: | 609-175-3 |
| Density: | 1.28 g/cm3 |
| Melting Point: | 119-121 °C |
| Boiling Point: | 439.3 °C at 760 mmHg |
| Flash Point: | 219.5 °C |
| Appearance: | Off-white sSolid |
| PSA: | 41.93000 |
| LogP: | 1.78820 |
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Specification
The Galantamine is an organic compound with the formula C17H21NO3. The systematic name of this chemical is galanthamine. With the CAS registry number 357-70-0, it is also named as 3,4-Dihydrogalanthamine. The product's categories are All Inhibitors; Inhibitors; Intermediates & Fine Chemicals; Pharmaceuticals. Besides, it is an off-white solid, which is used for the treatment of mild to moderate Alzheimer's disease and various memory impairments. Galantamine is indicated for mild to moderate Vascular Dementia and Alzheimer.
Physical properties about Galantamine are: (1)ACD/LogP: 1.75; (2)ACD/LogD (pH 5.5): -0.59; (3)ACD/LogD (pH 7.4): 1.12; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 2.94; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 49.83; (8)#H bond acceptors: 4; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 2; (11)Polar Surface Area: 30.93 Å2; (12)Index of Refraction: 1.636; (13)Molar Refractivity: 80.31 cm3; (14)Molar Volume: 223.9 cm3; (15)Polarizability: 31.83×10-24cm3; (16)Surface Tension: 56.6 dyne/cm; (17)Density: 1.28 g/cm3; (18)Flash Point: 219.5 °C; (19)Enthalpy of Vaporization: 73.39 kJ/mol; (20)Boiling Point: 439.3 °C at 760 mmHg; (21)Vapour Pressure: 1.71E-08 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES: O(c2c1O[C@H]4C[C@@H](O)/C=C\[C@@]43c1c(cc2)CN(C)CC3)C
(2)InChI: InChI=1/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1
(3)InChIKey: ASUTZQLVASHGKV-JDFRZJQEBY
(4)Std. InChI: InChI=1S/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1
(5)Std. InChIKey: ASUTZQLVASHGKV-JDFRZJQESA-N
The toxicity data is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 10mg/kg (10mg/kg) | Journal of Medicinal Chemistry. Vol. 37, Pg. 689, 1994. | |
| mouse | LD50 | subcutaneous | 14mg/kg (14mg/kg) | United States Patent Document. Vol. #4550113, | |
| rat | LD50 | intraperitoneal | 22900mg/kg (22900mg/kg) | United States Patent Document. Vol. #5177082, |