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| Name |
Heliotrine |
EINECS | N/A |
| CAS No. | 303-33-3 | Density | 1.19g/cm3 |
| PSA | 79.23000 | LogP | 0.26470 |
| Solubility | N/A | Melting Point |
125-126℃ |
| Formula | C16H27 N O5 | Boiling Point | 450.7°Cat760mmHg |
| Molecular Weight | 313.394 | Flash Point | 226.4°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | A poison by ingestion, intravenous, and intraperitoneal routes. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental tumorigenic data. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
Butanoicacid, 2-hydroxy-2-(1-methoxyethyl)-3-methyl-,(2,3,5,7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl)methyl ester, [1S-[1a,7[R*(S*)],7aa]]-; Heliotrine (6CI,8CI);(+)-Heliotrine; 7S-Heliotrine |
Heliotrine Chemical Properties
IUPAC Name: [(7S,8R)-7-Hydroxy-5,6,7,8-tetrahydro-3H-pyrrolizin-1-yl]methyl(2S)-2-hydroxy-2-[(1R)-1-methoxyethyl]-3-methylbutanoate
Molecular Formula: C16H27NO5
Molecular Weight: 313.44
Density: 1.19g/cm3
Melting Point: 128°C
Boiling Point: 450.7°C at 760mmHg
Flash Point: 226.4°C
Properties: Prisms from Me2CO
Solubility: soluble in H2O
Freely Rotating Bonds: 9
Polar Surface Area: 57.23 Å2
Index of Refraction: 1.541
Molar Refractivity: 82.19 cm3
Molar Volume: 261.4 cm3
Polarizability: 32.58× 10-24 cm3
Surface Tension: 48.5 dyne/cm
Enthalpy of Vaporization: 81.87 kJ/mol
Vapour Pressure: 5.13E-10 mmHg at 25°C
Storage temperature: 2-8°C
Transport information: 1544
The Cas Register Number of Heliotrine is 303-33-3.The chemical synonyms of Heliotrine (CAS NO.303-33-3) are Heliotron ; Heliotrine ; 7S-Heliotrine ; (+)-Heliotrine ; CCRIS 9196 ; AI3-51769 ; (7-hydroxy-5,6,7,8-tetrahydro-3H-pyrrolizin-1-yl)methyl-2-hydroxy-2-(1-methoxyethyl)-3-methylbutanoate ; (2S)-2-Hydroxy-2-[(R)-1-methoxyethyl]-3-methylbutyric acid [(1S,7aR)-2,3,5,7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl]methyl ; (2S)-2-Hydroxy-2-[(R)-1-methoxyethyl]-3-methylbutyric acid [(1S,7aR)-2,3,5,7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl]methyl ester .Product categories of Heliotrine (CAS NO.303-33-3) are HA -HTForensic and Veterinary Standards ; AlkaloidsAlphabetic ; Chemical Structure ; Drugs of Abuse ; Drugs and Metabolites ; H ;Neat CompoundsDrugs of Abuse ; Others .The molecular structure of Heliotrine (CAS NO.303-33-3) is
.
Heliotrine Uses
Heliotrine (CAS NO.303-33-3) is used as pharmaceutical.
Heliotrine Production
Heliotrine (CAS NO.303-33-3) can be obtained from the epigeal part of Heliotropium dasycarpum Ledeb . And also obtaining Heliotrine (CAS NO.303-33-3) from the plant raw material has been developed which consists in the extraction of the raw material with 80% ethanol, concentration to an aqueous residue, and reduction of the N-oxide form of heliotrine followed by extraction with chloroform, evaporation, and recrystallization from acetone. The yield of Heliotrine (CAS NO.303-33-3) is 75–85% of its amount in the raw material.
Heliotrine Toxicity Data With Reference
| 1. | mma-sat 1 mg/plate | MUREAV Mutation Research. 68 (1979),211. | ||
| 2. | dni-hmn:lvr 25 mg/L | IJEVAW International Journal of Environmental Studies. 1 (1971),107. | ||
| 3. | oms-hmn:lvr 10 mg/L | IJEVAW International Journal of Environmental Studies. 1 (1971),107. | ||
| 4. | sce-ham:lng 1200 µg/L | MUREAV Mutation Research. 142 (1985),209. | ||
| 5. | cyt-mam:leu 50 µmol/L | AJBSAM Australian Journal of Biological Sciences. 21 (1968),469. | ||
| 6. | orl-rat LDLo:50 mg/kg | NATUAS Nature. 179 (1957),361. | ||
| 7. | ipr-rat LD50:296 mg/kg | JPBAA7 Journal of Pathology and Bacteriology. 75 (1958),17. | ||
| 8. | ivn-rat LD50:274 mg/kg | AMPLAO AMA Archives of Pathology. 64 (1957),152. | ||
| 9. | ivn-mus LD50:251 mg/kg | AMPLAO AMA Archives of Pathology. 64 (1957),152. | ||
| 10. | ipr-mus LD50:296 mg/kg | JPBAA7 Journal of Pathology and Bacteriology. 75 (1958),17. | ||
| 11. | ipr-mam LDLo:250 mg/kg |
Heliotrine Consensus Reports
EPA Genetic Toxicology Program.
Heliotrine Safety Profile
A poison by ingestion, intravenous, and intraperitoneal routes. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental tumorigenic data. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Safety Statements: 22-36/37/39-45
S22: Do not breathe dust.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
HazardClass: 6.1(b)
RIDADR: 1544
PackingGroup: III
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