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Name	Hydrastinine	EINECS	N/A
CAS No.	6592-85-4	Density	1.332g/cm³
PSA	41.93000	LogP	0.83200
Solubility	N/A	Melting Point	117°
Formula	C₁₁H₁₃NO₃	Boiling Point	342.5°Cat760mmHg
Molecular Weight	207.229	Flash Point	161°C
Transport Information	N/A	Appearance	N/A
Safety	Poison by subcutaneous route. Can cause paralysis of vasomotor nerves and vagus endings. When heated to decomposition it emits highly toxic fumes of NO_x.	Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-ol;hydrastinine;1,3-Dioxolo(4,5-g)isoquinolin-5-ol,5,6,7,8-tetrahyro-6-methyl;1-hydroxy-6,7-methylenedioxy-2-methyl-1,2,3,4-tetrahydroisoquinoline;EINECS 229-533-9;6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-ol;1,3-Dioxolo[4,5-g]isoquinolin-5-ol,5,6,7,8-tetrahydro-6-methyl;1,3-Dioxolo[4,5-g]isoquinolin-5-ol, 5,6,7,8-tetrahydro-6-methyl-;Hydraztinine;

Hydrastinine Chemical Properties

IUPAC Name: 6-Methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-ol
Synonyms of Hydrastinine (CAS NO.6592-85-4) : 1,3-Dioxolo[4,5-g]isoquinolin-5-ol, 5,6,7,8-tetrahydro-6-methyl- ; 1-Hydroxy-6,7-methylenedioxy-2-methyl-1,2,3,4-tetrahydroisoquinoline ; 5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-ol (9CI) ; 5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-ol ; 6-Methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-ol
CAS NO:6592-85-4
Molecular Formula:C₁₁H₁₃NO₃
Molecular Weight :207.2258
Molecular Structure :
EINECS: 229-533-9
Index of Refraction: 1.617
Surface Tension: 54 dyne/cm
Density: 1.332 g/cm³
Flash Point: 161 °C
Enthalpy of Vaporization: 61.88 kJ/mol
Boiling Point: 342.5 °C at 760 mmHg
Vapour Pressure: 2.87E-05 mmHg at 25°C

Hydrastinine Uses

Hydrastinine (CAS NO.6592-85-4) was patented by Bayer as a haemostatic drug during 1910s.

Hydrastinine Production

Hydrastinine (CAS NO.6592-85-4) was produced by oxidative splitting of hydrastine hydrochloride with nitric acid in good yield.

Hydrastinine Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rabbit	LDLo	subcutaneous	300mg/kg (300mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
rat	LDLo	subcutaneous	1gm/kg (1000mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.

Hydrastinine Safety Profile

Poison by subcutaneous route. Can cause paralysis of vasomotor nerves and vagus endings. When heated to decomposition it emits highly toxic fumes of NO_x.

RIDADR 1544
HazardClass 6.1(b)
PackingGroup III

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