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Hydroxypropyl methylcellulose phthalate

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Name

Hydroxypropyl methylcellulose phthalate

EINECS 232-674-9
CAS No. 9050-31-1 Density 0.6 g/mL at 25oC(lit.)
PSA 57.46000 LogP 2.75280
Solubility N/A Melting Point >145oC (dec.)(lit.)
Formula C8H6O4.xC3H8O2.xCH4O.xUnspecified Boiling Point 456.7°C at 760 mmHg
Molecular Weight 240.30400 Flash Point 230°C
Transport Information N/A Appearance White Powder
Safety 24/25 Risk Codes N/A
Molecular Structure Molecular Structure of 9050-31-1 (Hydroxypropyl methylcellulose phthalate) Hazard Symbols N/A
Synonyms

HP 50F;HP 55F;HP 55UF;HPMCP;Hypromellose phthtalate (NF);Hydroxypropylmethylcellulose phthalate;HP 50 (cellulose derivative);Hypromellose phthtalate;Cellulose,esters,hydrogen 1,2-benzenedicarboxylate,2-hydroxypropyl methyl ether;Hydroxypropylmethylcellulose phthalate (JP14);HPMCP 55;Hydroxypropylmethyl Cellulose phthalate(HPMCP);Hydroxy propyl Methyl cellulose Phthalate (HPMCP-HP55);

 

Hydroxypropyl methylcellulose phthalate Specification

The systematic name of Hydroxypropyl methylcellulose phthalate is Cellulose, hydrogen 1,2-benzenedicarboxylate, 2-hydroxypropyl methyl ether. With the CAS registry number 9050-31-1, it is also named as HP 55. The other registry numbers are 168395-88-8, 37324-31-5, 42612-68-0, 52624-22-3 and 9087-42-7. And the classification code is TSCA Flag XU [Exempt from reporting under the Inventory Update Rule]. It is white to off-white free-flowing flakes or granules which is stable under normal temperatures and pressures. Additionally, Hydroxypropyl methylcellulose phthalate should be sealed in the container and stored in the cool and dry place. Besides, people should avoid contact with skin and eyes.

The following are the toxicity data which has been tested.

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD oral > 15gm/kg (15000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 1017, 1970.

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