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Hygromycin B

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Name

Hygromycin B

EINECS 250-545-5
CAS No. 31282-04-9 Density 1.67 g/cm3
PSA 272.06000 LogP -5.47910
Solubility Miscible with water, methanol, buffer solution and ethanol. Immiscible with less polar solvents. Melting Point 160-180 °C
Formula C20H37N3O13 Boiling Point 897.6 °C at 760 mmHg
Molecular Weight 527.526 Flash Point 496.7 °C
Transport Information UN 3462 6.1/PG 1 Appearance Amorphous solid or tan powder.
Safety 23-26-28-36/37/39-45-22-36 Risk Codes 26/27/28-41-42/43-40
Molecular Structure Molecular Structure of 31282-04-9 (Hygromycin B) Hazard Symbols VeryT+, HarmfulXn
Synonyms

HygromycinB (7CI);Antihelmycin;Hygromix 2.4;Hygromix-8;Hygrovetin;Hygrovetine;

 

Hygromycin B Specification

The Hygromycin B , with cas registry number of 31282-04-9, also has other registry numbers which are 1403-76-5, 8052-92-4, 8052-93-5. It is also called for Hygrovectine ; Hygromix-8 ; Antihelmycin ; Hygrovetine , and O-6-Amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1-2-3)-o-beta-D-talopyranosyl-(1-5)-2-deoxy-N3-methyl-D-streptamine . Hygromycin B is from streptomyces hygroscopicus. It belongs to the categories of (1) Anthelmintics ; (2) Anti-Bacterial Agents ; (3) Anti-Infective Agents ; (4) Antiparasitic Agents ; (5) Drug / Therapeutic Agent ; (6) Natural Product.

Physical properties of Hygromycin B : (1) ACD/LogP: 0.64 ; (2) # of Rule of 5 Violations: 3 ; (3) ACD/LogD (pH 5.5): -4.36 ; (4) ACD/LogD (pH 7.4): -2.58 ; (5) ACD/BCF (pH 5.5): 1 ; (6) ACD/BCF (pH 7.4): 1 ; (7) ACD/KOC (pH 5.5): 1 ; (8) ACD/KOC (pH 7.4): 1 ; (9) #H bond acceptors: 16 ; (10) #H bond donors: 13 ; (11) #Freely Rotating Bonds: 16 ; (12) Index of Refraction: 1.672 ; (13) Molar Refractivity: 118.04 cm3 ; (14) Molar Volume: 315.1 cm3 ; (15) Surface Tension: 103.2 dyne/cm ; (16) Enthalpy of Vaporization: 148.17 kJ/mol.

Uses of Hygromycin B : Hygromycin B , very safe de-worming drug, can effectively kill the roundworm of pigs, whipworm and chickens' roundworm, and have antibacterial effect. And it also can be used for chicken feed (the dosage of 8 (800 × 104U)-12 (1200 × 104U) g / t, Laying disabled, withdrawal period 3 days) and the following 4-month-old pig feed (the dosage of 10 -- 13g / t, withdrawal period of 15 days, to avoid eye contact with human skin).

When you are using this chemical, please be cautious about it as the following:
The Hygromycin B is very toxic by inhalation, in contact with skin and if swallowed. It may cause sensitization by inhalation and skin contact. It has risk of serious damage to the eyes and limited evidence of a carcinogenic effect. Before use it, wear suitable protective clothing, gloves and eye/face protection. Do not breathe vapour and dust. If contact with eyes, rinse immediately with plenty of water and seek medical advice. In case of feel unwell, seek medical advice immediately. It is a poison by intraperitoneal route. When heated to decomposition, it emits toxic fumes of NOx.

You can still convert the following datas into molecular structure:
(1)SMILES:O1[C@H]4[C@@H](OC12O[C@@H]([C@H](O)[C@@H](O)[C@H]2O)[C@@H](N)CO)[C@@H](O)[C@H](O[C@H]4O[C@@H]3[C@@H](O)[C@H](N)C[C@H](NC)[C@H]3O)CO;
(2)InChI:InChI=1/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6+,7+,8-,9+,10-,11+,12-,13-,14-,15-,16+,17+,18-,19+,20?/m1/s1;
(3)InChIKey:GRRNUXAQVGOGFE-KPBUCVLVBD

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intraperitoneal 13mg/kg (13mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 38(5), Pg. 11, 1973.
mouse LD50 intravenous 6mg/kg (6mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 1, Pg. 202, 1980.
mouse LD50 oral 46000units/kg (46000units/kg)   Pharmaceutical Chemistry Journal Vol. 1, Pg. 396, 1967.
mouse LDLo intraperitoneal 6mg/kg (6mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Journal of Pharmacology and Experimental Therapeutics. Vol. 281, Pg. 992, 1997.
rat LC50 inhalation 2220ug/m3/4H (2.22mg/m3) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE

BEHAVIORAL: AGGRESSION
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 38(5), Pg. 11, 1973.
rat LD50 intraperitoneal 63mg/kg (63mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 38(5), Pg. 11, 1973.

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