1. Introduction of Imipenem
Imipenem is one kind of white crystalline powder. The IUPAC name of this chemical is (5R,6S)-3-[2-(aminomethylideneamino)ethylsulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid hydrate. In addition, Imipenem belongs to Intermediates & Fine Chemicals;Pharmaceuticals. Besides, Imipenem Classification Code is Anti-Bacterial Agents; Anti-Infective Agents; Antibacterial. The water solubility of Imipenem is 10 mg/mL.

2. Properties of Imipenem
Physical properties about Imipenem are:
(1)ACD/LogP: -2.29; (2)ACD/LogD (pH 5.5): -4.74; (3)ACD/LogD (pH 7.4): -4.79; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 7; (9)#H bond donors: 4; (10)#Freely Rotating Bonds: 7; (11)Polar Surface Area: 96.74 Å²; (12)Flash Point: 296.9 °C; (13)Enthalpy of Vaporization: 97.84 kJ/mol; (14)Boiling Point: 567.3 °C at 760 mmHg; (15)Vapour Pressure: 3.11E-15 mmHg at 25°C.

3. Structure Descriptors of Imipenem
You can still convert the following datas into molecular structure:
(1)SMILES: O=C(O)/C1=C(\SCC/N=C/N)C[C@H]2N1C(=O)[C@@H]2[C@H](O)C.O
(2)InChI: InChI=1/C12H17N3O4S.H2O/c1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17;/h5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19);1H2/t6-,7-,9-;/m1./s1
(3)InChIKey: GSOSVVULSKVSLQ-JJVRHELEBB

4. Uses of Imipenem
Imipenem can be used in the treatment of urethral infection, and lower respiratory tract infection, intra-abdominal infections, skin and soft tissue infection, digestive system infection, osteomyelitis, prostatitis, bacteremia, etc. It is semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative. Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases.

Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with cilastatin, a renal dipeptidase inhibitor.

5. Production of Imipenem
Preparation of Imipenem: it can be prepared by 6-APA. The equation is as follows: