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| CAS No.: | 11061-68-0 |
|---|---|
| Name: | Insulin (human) |
| Molecular Structure: | |
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| Formula: | C257H383N65O77S6 |
| Molecular Weight: | 5807.57 |
| Synonyms: | Humulin;Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-;Humulin S;Incelligent SG;Insugen;Insulin (Cercopithecus aethiops);Insulin (Macaca fascicularis);Insulin (Macaca mulatta);Insulin (Pantroglodytes);Isuhuman;Jusline;VelosulineHM;Viaject;Novolin;NovolinR;Novolin ge Toronto;Penfil R;Ultraphane;Umulin;Velosulin HM;Human Protaphane;H-Tronin;Actrapid;Actrapid HM;Biohulin; |
| EINECS: | 234-291-2 |
| Solubility: | Soluble in acidic solution |
| Safety: | 22-24/25 |
| PSA: | 2450.87000 |
| LogP: | 5.20780 |
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Specification
The Insulin human, with the CAS registry number 11061-68-0, is also known as Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-. It belongs to the product categories of Insulin and related Pharmacopoeia (USP); Pharmacopoeial Organics; Plasma & Blood Proteins; Hormones Serum-free Media; Hybridoma Media Supplements Hematopoietic Stem Cell Biology; Media Supplements Neural Stem Cell Biology; Hybridoma Platform; Cell Culture; Hematopoietic Stem Cell Expansion/Differentiation; Islet Stem Cell Differentiation; Media Supplements; Neural Stem Cell Isolation/Expansion; Reagents and Supplements. Its EINECS number is 234-291-2. This chemical's molecular formula is C257H383N65O77S6 and molecular weight is 5807.57. Its classification codes are: (1)Antidiabetic; (2)Drug / Therapeutic Agent; (3)Hypoglycemic agents. It should be sealed and stored in a cool and dry place. You should not breathe dust. When using it, you must avoid contact with eyes. It is a protein that has the normal structure of the natural antidiabetic principle produced by the human pancreas.
You can still convert the following datas into molecular structure:
(1)InChI: InChI=1/C257H383N65O77S6/c1-29-131(23)205(313-193(339)104-259)252(393)317-204(130(21)22)248(389)288-159(75-82-200(349)350)217(358)282-156(71-78-189(263)335)221(362)308-183-116-403-404-117-184-243(384)305-178(111-324)240(381)294-162(88-123(7)8)225(366)295-168(95-140-53-61-146(329)62-54-140)228(369)283-154(69-76-187(261)333)218(359)290-161(87-122(5)6)223(364)285-158(74-81-199(347)348)220(361)302-174(101-190(264)336)235(376)298-170(97-142-57-65-148(331)66-58-142)231(372)309-182(242(383)304-176(255(396)397)103-192(266)338)115-402-401-114-181(214(355)273-107-194(340)278-153(72-79-197(343)344)216(357)281-151(51-42-84-271-257(267)268)212(353)272-108-195(341)279-166(93-138-46-36-32-37-47-138)227(368)297-167(94-139-48-38-33-39-49-139)230(371)299-171(98-143-59-67-149(332)68-60-143)238(379)320-208(135(27)327)254(395)322-85-43-52-186(322)246(387)286-152(50-40-41-83-258)222(363)321-209(136(28)328)256(398)399)311-250(391)203(129(19)20)316-236(377)164(90-125(11)12)292-229(370)169(96-141-55-63-147(330)64-56-141)296-224(365)160(86-121(3)4)289-210(351)133(25)277-215(356)157(73-80-198(345)346)287-247(388)202(128(17)18)315-237(378)165(91-126(13)14)293-233(374)173(100-145-106-270-120-276-145)301-239(380)177(110-323)280-196(342)109-274-213(354)180(113-400-405-118-185(310-244(183)385)245(386)319-207(134(26)326)253(394)306-179(112-325)241(382)318-206(132(24)30-2)251(392)312-184)307-226(367)163(89-124(9)10)291-232(373)172(99-144-105-269-119-275-144)300-219(360)155(70-77-188(262)334)284-234(375)175(102-191(265)337)303-249(390)201(127(15)16)314-211(352)150(260)92-137-44-34-31-35-45-137/h31-39,44-49,53-68,105-106,119-136,150-186,201-209,323-332H,29-30,40-43,50-52,69-104,107-118,258-260H2,1-28H3,(H2,261,333)(H2,262,334)(H2,263,335)(H2,264,336)(H2,265,337)(H2,266,338)(H,269,275)(H,270,276)(H,272,353)(H,273,355)(H,274,354)(H,277,356)(H,278,340)(H,279,341)(H,280,342)(H,281,357)(H,282,358)(H,283,369)(H,284,375)(H,285,364)(H,286,387)(H,287,388)(H,288,389)(H,289,351)(H,290,359)(H,291,373)(H,292,370)(H,293,374)(H,294,381)(H,295,366)(H,296,365)(H,297,368)(H,298,376)(H,299,371)(H,300,360)(H,301,380)(H,302,361)(H,303,390)(H,304,383)(H,305,384)(H,306,394)(H,307,367)(H,308,362)(H,309,372)(H,310,385)(H,311,391)(H,312,392)(H,313,339)(H,314,352)(H,315,378)(H,316,377)(H,317,393)(H,318,382)(H,319,386)(H,320,379)(H,321,363)(H,343,344)(H,345,346)(H,347,348)(H,349,350)(H,396,397)(H,398,399)(H4,267,268,271)/t131-,132-,133-,134?,135?,136?,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,178-,179-,180-,181-,182-,183-,184-,185-,186-,201-,202-,203-,204-,205-,206-,207-,208-,209-/m0/s1
(2)Smiles: N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]1C(NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)[C@H](O)C)CCCCN)CCC2)[C@H](O)C)Cc2ccc(cc2)O)Cc2ccccc2)Cc2ccccc2)=O)CCCNC(N)=N)=O)CCC(=O)O)=O)=O)CSSC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]2NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CN)=O)[C@@H](C)CC)=O)C(C)C)=O)CCC(=O)O)=O)CCC(=O)N)=O)CSSC2)=O)CSSC1)=O)[C@H](O)C)=O)CO)=O)[C@@H](C)CC)=O)=O)CO)=O)CC(C)C)=O)Cc1ccc(cc1)O)=O)CCC(=O)N)=O)CC(C)C)=O)CCC(=O)O)=O)CC(=O)N)=O)Cc1ccc(cc1)O)=O)C(=O)N[C@H](C(O)=O)CC(=O)N)=O)C(C)C)=O)CC(C)C)=O)Cc1ccc(cc1)O)=O)CC(C)C)=O)C)=O)CCC(=O)O)=O)C(C)C)CC(C)C)Cc1cnc[nH]1)CO)=O)=O)CC(C)C)=O)Cc1cnc[nH]1)=O)CCC(=O)N)=O)CC(=O)N)=O)C(C)C)=O)Cc1ccccc1
The toxicity data is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 3937units/kg (3937units/kg) | Yakkyoku. Pharmacy. Vol. 37, Pg. 1633, 1986. | |
| mouse | LD50 | intravenous | > 4ku/kg (4000iu/kg) | Yakkyoku. Pharmacy. Vol. 37, Pg. 1633, 1986. | |
| mouse | LD50 | subcutaneous | > 4ku/kg (4000iu/kg) | Yakkyoku. Pharmacy. Vol. 37, Pg. 1633, 1986. | |
| rat | LD50 | intraperitoneal | > 4ku/kg (4000iu/kg) | Yakkyoku. Pharmacy. Vol. 37, Pg. 1633, 1986. | |
| rat | LD50 | intravenous | > 4ku/kg (4000iu/kg) | Yakkyoku. Pharmacy. Vol. 37, Pg. 1633, 1986. | |
| rat | LD50 | subcutaneous | > 4ku/kg (4000iu/kg) | Yakkyoku. Pharmacy. Vol. 37, Pg. 1633, 1986. |