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Isoniazid

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Isoniazid

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Isoniazid Chemical Properties


IUPAC Name: Pyridine-4-carbohydrazide
Molecular Formula: C6H7N3O
Molecular Weight: 137.13928 g/mol
Canonical SMILES: C1=CN=CC=C1C(=O)NN
InChI: InChI=1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
Classification Code: Anti-Bacterial Agents; Anti-Infective Agents; Antibacterial [tuberculostatic]; Antilipemic Agents; Antimetabolites; Antitubercular agents; Drug / Therapeutic Agent; Fatty Acid Synthesis Inhibitors; Human Data; Mutation data; Reproductive Effect; Skin / Eye Irritant; Tumor data
Melting Point: 171.4 °C
Index of Refraction: 1.583
Molar Refractivity: 36.86 cm3
Molar Volume: 110.1 cm3
Surface Tension: 57.8 dyne/cm
Density of Isoniazid (CAS NO.7640-37-1): 1.244 g/cm3

Isoniazid Uses

 Isoniazid (CAS NO.7640-37-1) is the first-line antituberculosis medication in prevention and treatment. It is the most potent and selective of the tuberculostatic antibacterial agents.

Isoniazid Production

 Isoniazid may be prepared by the base hydrolysis of 4-cyanopyridine to give the amide, followed by displacement of ammonia by hydrazine:
                  

Isoniazid Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intraperitoneal 325mg/kg (325mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Klinische Wochenscrift. Vol. 30, Pg. 959, 1952.
child TDLo oral 125mg/kg (125mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: COMA
Annals of Emergency Medicine. Vol. 17, Pg. 73, 1988.
child TDLo oral 195mg/kg (195mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: HEADACHE
Japanese Journal of Toxicology. Vol. 12, Pg. 225, 1999.
child TDLo oral 3600mg/kg/43W (3600mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: ATAXIA

BEHAVIORAL: TREMOR
Canadian Medical Association Journal. Vol. 148, Pg. 49, 1993.
dog LD50 oral 50mg/kg (50mg/kg)   American Review of Tuberculosis. Vol. 65, Pg. 392, 1952.
guinea pig LD50 intramuscular 255mg/kg (255mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie. Vol. 9, Pg. 226, 1952.
guinea pig LD50 intraperitoneal 195mg/kg (195mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Klinische Wochenscrift. Vol. 30, Pg. 959, 1952.
guinea pig LD50 intravenous 220mg/kg (220mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Archiv fuer Toxikologie. Vol. 22, Pg. 80, 1966.
guinea pig LD50 oral 255mg/kg (255mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie. Vol. 9, Pg. 226, 1952.
guinea pig LD50 subcutaneous 195mg/kg (195mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie. Vol. 9, Pg. 226, 1952.
human LDLo oral 100mg/kg (100mg/kg) PERIPHERAL NERVE AND SENSATION: STRUCTURAL CHANGE IN NERVE OR SHEATH American Review of Respiratory Disease. Vol. 105, Pg. 206, 1972.
infant TDLo oral 91mg/kg (91mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Pediatrics. Vol. 95, Pg. 700, 1995.
man LDLo oral 116mg/kg (116mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: EMPHYSEMA
Journal of Analytical Toxicology. Vol. 16, Pg. 57, 1992.
man LDLo oral 523mg/kg/17W- (523mg/kg) LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"

LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)"
JAMA, Journal of the American Medical Association. Vol. 176, Pg. 877, 1961.
man TDLo oral 39mg/kg/9D-I (39mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Southern Medical Journal. Vol. 75, Pg. 81, 1982.
man TDLo oral 100mg/kg/3W-C (100mg/kg) BEHAVIORAL: ANOREXIA (HUMAN

SKIN AND APPENDAGES (SKIN): SWEATING: OTHER

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
American Review of Respiratory Disease. Vol. 106, Pg. 849, 1972.
man TDLo oral 430mg/kg (430mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Neurology. Vol. 20, Pg. 299, 1970.
mouse LD50 intramuscular 137mg/kg (137mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
American Review of Tuberculosis. Vol. 65, Pg. 376, 1952.
mouse LD50 intraperitoneal 100mg/kg (100mg/kg)   National Technical Information Service. Vol. AD277-689,
mouse LD50 intravenous 149mg/kg (149mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 122, Pg. 110, 1958.
mouse LD50 oral 133mg/kg (133mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
American Review of Tuberculosis. Vol. 65, Pg. 376, 1952.
mouse LD50 subcutaneous 125mg/kg (125mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Yakugaku Zasshi. Journal of Pharmacy. Vol. 81, Pg. 1225, 1961.
rabbit LD50 intracrebral > 12mg/kg (12mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie. Vol. 9, Pg. 226, 1952.
rabbit LD50 intramuscular 155mg/kg (155mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie. Vol. 9, Pg. 226, 1952.
rabbit LD50 intraperitoneal 147mg/kg (147mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie. Vol. 9, Pg. 226, 1952.
rabbit LD50 intravenous 94mg/kg (94mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD American Review of Tuberculosis. Vol. 65, Pg. 376, 1952.
rabbit LD50 oral 250mg/kg (250mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 22, 1962.
rabbit LD50 subcutaneous 135mg/kg (135mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie. Vol. 9, Pg. 226, 1952.
rat LD50 intramuscular 400mg/kg (400mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Therapie. Vol. 8, Pg. 62, 1953.
rat LD50 intraperitoneal 335mg/kg (335mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie. Vol. 9, Pg. 226, 1952.
rat LD50 intravenous 365mg/kg (365mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 409, 1976.
rat LD50 oral 1250mg/kg (1250mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 409, 1976.
 
rat LD50 subcutaneous 329mg/kg (329mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 119, Pg. 444, 1957.
women TDLo oral 12mg/kg/2D-I (12mg/kg) BEHAVIORAL: TOXIC PSYCHOSIS

BEHAVIORAL: ATAXIA
Neurology. Vol. 34, Pg. 703, 1984.
women TDLo oral 90200ug/kg/7D (90.2mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: HEADACHE

CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE
Pediatrics. Vol. 97, Pg. 782, 1996.
women TDLo oral 99300ug/kg (99.3mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: NAUSEA OR VOMITING
Pediatrics. Vol. 95, Pg. 700, 1995.
women TDLo oral 11250mg/kg (11250mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Anaesthesia. Vol. 47, Pg. 781, 1992.

 

Isoniazid Specification

Isoniazid (CAS NO.7640-37-1), its Synonyms are 4-(Hydrazinocarbonyl)pyridine ; 4-Pyridinecarbonylhydrazine ; 4-Pyridinecarboxylic acid, hydrazide ; 4-Pyridinecarboxylic hydrazide ; 4-Pyridylcarbonylhydrazide ; Antimicina ; Antituberkulosum ; Armazid ; Armazide ; Isonicotinic acid hydrazide ; Isonicotinic hydrazide ; Isonicotinohydrazide .

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