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K-Strophanthidine

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Name

K-Strophanthidine

EINECS 200-626-6
CAS No. 66-28-4 Density 1.432 g/cm3
Solubility Melting Point 169°C
Formula C23H32 O6 Boiling Point 620.7 °C at 760 mmHg
Molecular Weight 404.55 Flash Point 214.9 °C
Transport Information UN 2811 6 Appearance
Safety A deadly poison by intravenous routes. When heated to decomposition it emits acrid smoke and irritating fumes. Risk Codes 26/27/28
Molecular Structure Molecular Structure of 66-28-4 (Card-20(22)-enolide,3,5,14-trihydroxy-19-oxo-, (3b,5b)-) Hazard Symbols VeryT+
Synonyms

5b-Card-20(22)-enolide, 3b,5,14-trihydroxy-19-oxo-(7CI,8CI); Strophanthidin (6CI); Apocymarin; Convallatoxigenin; Corchorin;Corchoside A aglycon; Corchsularin; Erysimupicrone; Erysimupikron; NSC 86078;Strophanthidin K; Strophanthidine; k-Strophanthidin

 

K-Strophanthidine Chemical Properties

IUPAC Name: (3S,5S,8R,9S,10S,13R,14S,17R)-3,5,14-Trihydroxy-13-methyl-17-(5-oxo-2H-furan-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde
CAS: 66-28-4
EINECS: 200-626-6
Following is the Molecular Structure of  K-Strophanthidine (66-28-4):

SMILES: O=C/1OCC(=C\1)\[C@@H]2[C@@]4([C@](O)(CC2)[C@@H]5CC[C@]3(O)C[C@@H](O)CC[C@]3(C=O)[C@H]5CC4)C
InChI: InChI=1/C23H32O6/c1-20-6-3-17-18(4-8-22(27)11-15(25)2-7-21(17,22)13-24)23(20,28)9-5-16(20)14-10-19(26)29-12-14/h10,13,15-18,25,27-28H,2-9,11-12H2,1H3/t15-,16+,17-,18+,20+,21-,22-,23-/m0/s1
InChIKey: ODJLBQGVINUMMR-HZXDTFASBJ
Std.InChI: InChI=1S/C23H32O6/c1-20-6-3-17-18(4-8-22(27)11-15(25)2-7-21(17,22)13-24)23(20,28)9-5-16(20)14-10-19(26)29-12-14/h10,13,15-18,25,27-28H,2-9,11-12H2,1H3/t15-,16+,17-,18+,20+,21-,22-,23-/m0/s1
Std.InChIKey: ODJLBQGVINUMMR-HZXDTFASSA-N 
Molecular Formula: C23H32O6
Molecular Weight: 404.5
Melting Point: 169℃
Boiling Point: 620.7℃ at 760mmHg
Flash Point: 214.9℃
Molar Volume: 282.3cm3
Density: 1.432g/cm3
Molar Refractivity: 106.07cm3
Surface Tension: 82.1dyne/cm
Polarizability: 42.05 10-24cm3
Enthalpy of Vaporization: 105.46kJ/mol
Vapour Pressure: 5.25E-18mmHg at 25℃

K-Strophanthidine Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intravenous 224ug/kg (0.224mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 103, Pg. 420, 1951.
cat LDLo unreported 260ug/kg (0.26mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 148, Pg. 471, 1964.
guinea pig LDLo intravenous 240ug/kg (0.24mg/kg) CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 251, 1965.
mammal (species unspecified) LDLo intravenous 526ug/kg (0.526mg/kg)   Acta Pharmaceutica Jugoslavica. Vol. 24, Pg. 179, 1974.
mouse LD50 intracrebral 63ug/kg (0.063mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 908, 1961.
mouse LD50 intravenous 330ug/kg (0.33mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 8(2), Pg. 224, 1982.
rabbit LDLo intravenous 110ug/kg (0.11mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 185, Pg. 329, 1937.

 

K-Strophanthidine Safety Profile

Hazard Codes:  T+ Very toxic.
Risk Statements: 26/27/28
R26/27/28: Very Toxic by inhalation, in contact with skin and if swallowed.
Safety Statements: 22-36/37/39-45
S22: Do not breathe dust.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible).
RIDADR: UN 2811 6.1/PG 1
WGK: Germany 3
RTECS: FH5425000
A deadly poison by intravenous routes.

K-Strophanthidine Specification

 K-Strophanthidine (66-28-4),which also can be called for K-Strophanthidin ; Cymarigenen ; 5Beta,20[22]-cardenolide-19-one-3beta,5,14-triol ; 3Beta,5,14-trihydroxy-19-oxo-5beta,20[22]-cardenolide ; Strophanthidin k ; Strophanthidin ; 19-Oxo-cardogenen-(20:22)-triol-(3-beta,5,14) ; 3,5,14-Trihydroxy-19-oxo-,(3-beta,5-beta)-card-20(22)-enolid .The appropriate storage temperature of K-Strophanthidine (66-28-4) is -20℃.

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