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Basic Information
| CAS No.: | 25389-94-0 |
|---|---|
| Name: | Kanamycin sulfate |
| Molecular Structure: | |
|
|
|
| Formula: | C18H36N4O11•H2O4S |
| Molecular Weight: | 582.584 |
| Synonyms: | Kanamycin Mono Sulfate;Kanamycin Mono Sulphate;Prestwick_596;Otokalixin;Kanacedin;Kantrex;Kanabristol;Cantrex;Kanatrol;Kanaqua;Kantrex (TN);Kanescin;Ophtalmokalixan;Cristalomicina;Kannasyn;Klebcil;133-92-6;Kanasig;Kanamytrex;Kantrim;2-(aminomethyl)-6-[4,6-diamino-3-[4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxy-cyclohexyl]oxy-oxane-3,4,5-triol; sulfuric acid; |
| EINECS: | 246-933-9 |
| Density: | 1.3619 (rough estimate) |
| Melting Point: | 250 °C |
| Boiling Point: | 943.2 °C at 760 mmHg |
| Flash Point: | 524.2 °C |
| Solubility: | Soluble in water at 10mg/ml |
| Appearance: | Off-white powder |
| Hazard Symbols: |
 T
|
| Risk Codes: | 61 |
| Safety: | 22-24/25-45 |
| PSA: | 365.59000 |
| LogP: | -4.06220 |
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Kanamycin sulfate
Chemistry
Molecular Formula: C18H38N4O15S
Formula Weight: 582.58
mp : 250°C
refractive index : 117.5 ° (C=1, H2O)
storage temp. : 2-8°C
solubility : H2O: 10-50 mg/mL As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 5 days.
KANAMYCIN SULFATE is an aminoglycoside antibiotic, available in both oral and intravenous forms.
Formula Weight: 582.58
mp : 250°C
refractive index : 117.5 ° (C=1, H2O)
storage temp. : 2-8°C
solubility : H2O: 10-50 mg/mL As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 5 days.
KANAMYCIN SULFATE is an aminoglycoside antibiotic, available in both oral and intravenous forms.
Uses
KANAMYCIN SULFATE is used in molecular biology as a selective agent most commonly to isolate bacteria (e.g., E. coli) which have taken up genes (e.g., of plasmids) coupled to a gene coding for kanamycin resistance (primarily Neomycin phosphotransferase II [NPT II/Neo]).
Toxicity Data With Reference
| 1. | ims-cld TDLo:390 mg/kg:EAR | JOPDAB Journal of Pediatrics. 60 (1962),230. | ||
| 2. | orl-rat LD50:>4 g/kg | JJANAX Japanese Journal of Antibiotics. 28 (1975),415. | ||
| 3. | ipr-rat LD50:3200 mg/kg | JJANAX Japanese Journal of Antibiotics. 28 (1975),415. | ||
| 4. | ivn-rat LD50:225 mg/kg | JJANAX Japanese Journal of Antibiotics. 28 (1975),415. | ||
| 5. | orl-mus LD50:17,500 mg/kg | DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. 6 (1982),173. | ||
| 6. | ipr-mus LDLo:1914 mg/kg | AIMDAP Archives of Internal Medicine. 119 (1967),493. | ||
| 7. | scu-mus LD50:2150 mg/kg | JJANAX Japanese Journal of Antibiotics. 28 (1975),415. | ||
| 8. | ivn-mus LD50:180 mg/kg | ANTBAL Antibiotiki. 24 (1979),60. | ||
| 9. | ims-mus LDLo:1914 mg/kg | AIMDAP Archives of Internal Medicine. 119 (1967),493. | ||
| 10. | ivn-rbt LD50:550 mg/kg | JJANAX Japanese Journal of Antibiotics. 28 (1975),415. |
Safety Profile
Hazard Codes : T
Risk Statements : 61
Safety Statements : 22-24/25-45
WGK Germany : 3
RTECS : NZ3225030
A poison by intravenous route. Moderately toxic by intraperitoneal, subcutaneous, and intramuscular routes. Human systemic effects: hearing acuity changes. When heated to decomposition it emits very toxic NOx and SOx. See also KANAMYCIN SULFATE (1:1) SALT.
Risk Statements : 61
Safety Statements : 22-24/25-45
WGK Germany : 3
RTECS : NZ3225030
A poison by intravenous route. Moderately toxic by intraperitoneal, subcutaneous, and intramuscular routes. Human systemic effects: hearing acuity changes. When heated to decomposition it emits very toxic NOx and SOx. See also KANAMYCIN SULFATE (1:1) SALT.