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KANAMYCIN SULFATE
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  • Name KANAMYCIN SULFATE
  • EINECS246-933-9
  • CAS No. 25389-94-0
  • Density1.3619 (rough estimate)
  • PSA365.59000
  • LogP-4.06220
  • SolubilitySoluble in water at 10mg/ml
  • Melting Point250 °C
  • FormulaC18H36N4O11•H2O4S
  • Boiling Point943.2 °C at 760 mmHg
  • Molecular Weight582.584
  • Flash Point524.2 °C
  • Transport InformationN/A
  • AppearanceOff-white powder
  • Safety22-24/25-45
  • Risk Codes61
  • Molecular Structure
    Molecular Structure of 25389-94-0 (Kanamycin sulfate)
  • Hazard SymbolsToxicT
  • SynonymsToxicT
  • Article Data2

KANAMYCIN SULFATE Chemical Properties

Molecular Formula: C18H38N4O15S
Formula Weight: 582.58
mp : 250°C
refractive index : 117.5 ° (C=1, H2O) 
storage temp. : 2-8°C
solubility : H2O: 10-50 mg/mL As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 5 days.
KANAMYCIN SULFATE is an aminoglycoside antibiotic, available in both oral and intravenous forms.

KANAMYCIN SULFATE Uses

KANAMYCIN SULFATE is used in molecular biology as a selective agent most commonly to isolate bacteria (e.g., E. coli) which have taken up genes (e.g., of plasmids) coupled to a gene coding for kanamycin resistance (primarily Neomycin phosphotransferase II [NPT II/Neo]).

KANAMYCIN SULFATE Toxicity Data With Reference

1.   

ims-cld TDLo:390 mg/kg:EAR

   JOPDAB    Journal of Pediatrics. 60 (1962),230.
2.   

orl-rat LD50:>4 g/kg

   JJANAX    Japanese Journal of Antibiotics. 28 (1975),415.
3.   

ipr-rat LD50:3200 mg/kg

   JJANAX    Japanese Journal of Antibiotics. 28 (1975),415.
4.   

ivn-rat LD50:225 mg/kg

   JJANAX    Japanese Journal of Antibiotics. 28 (1975),415.
5.   

orl-mus LD50:17,500 mg/kg

   DRUGAY    Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. 6 (1982),173.
6.   

ipr-mus LDLo:1914 mg/kg

   AIMDAP    Archives of Internal Medicine. 119 (1967),493.
7.   

scu-mus LD50:2150 mg/kg

   JJANAX    Japanese Journal of Antibiotics. 28 (1975),415.
8.   

ivn-mus LD50:180 mg/kg

   ANTBAL    Antibiotiki. 24 (1979),60.
9.   

ims-mus LDLo:1914 mg/kg

   AIMDAP    Archives of Internal Medicine. 119 (1967),493.
10.   

ivn-rbt LD50:550 mg/kg

   JJANAX    Japanese Journal of Antibiotics. 28 (1975),415.

KANAMYCIN SULFATE Safety Profile

Hazard Codes : T
Risk Statements : 61
Safety Statements : 22-24/25-45
WGK Germany : 3
RTECS : NZ3225030
A poison by intravenous route. Moderately toxic by intraperitoneal, subcutaneous, and intramuscular routes. Human systemic effects: hearing acuity changes. When heated to decomposition it emits very toxic NOx and SOx. See also KANAMYCIN SULFATE (1:1) SALT.
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