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Karminomycin

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Karminomycin

EINECS
CAS No. 39472-31-6 Density 1.63g/cm3
Solubility Melting Point
Formula C26H27NO10 Boiling Point 750.6°Cat760mmHg
Molecular Weight 513.4933 Flash Point 407.7°C
Transport Information Appearance
Safety Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects by intravenous route: anorexia, hallucinations and distorted perceptions, thrombosis, nausea or vomiting, fatty liver degeneration, impaired liver function, endocrine changes, and leukopenia (reduced white blood cell count). An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and fumes. Risk Codes
Molecular Structure Molecular Structure of 39472-31-6 (KARMINOMYCIN			) Hazard Symbols
Synonyms

 

Karminomycin Chemical Properties

IUPAC:  (7S,9S)-9-Acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-4,6,9,11-tetrahydroxy-8,10-dihydro-7H-tetracene-5,12-dione
 Karminomycin with CAS NO.of  39472-31-6 is also called for Carubicin ; CCRIS 961 ; Carminomycin ; STOCK1N-41435 ; AIDS-166741 ; CID443831 ; NCGC00159344-02 ; C12432  ; O-Demethyldaunomycin  and so on.
Molecular Weight: 513.49
Molecular Formula: C26H27NO10
ACD/LogP: 3.54  
ACD/LogD (pH 5.5): 0.78 
ACD/LogD (pH 7.4): 1.11 
ACD/BCF (pH 5.5): 1 
ACD/BCF (pH 7.4): 1.08 
ACD/KOC (pH 5.5): 3.49 
ACD/KOC (pH 7.4): 7.49 
H bond acceptors: 11 
H bond donors: 7 
Freely Rotating Bonds: 9
Heavy Atom Count: 37
Formal Charge: 0
Complexity: 944
Isotope Atom Count: 0
Defined Atom StereoCenter Count: 6
Undefined Atom StereoCenter Count: 0
Defined Bond StereoCenter Count: 0
Undefined Bond StereoCenter Count: 0
Covalently-Bonded Unit Count: 1 
Index of Refraction: 1.726 
Molar Refractivity: 125.14 cm
Molar Volume: 314.6 cm
Surface Tension: 99.8 dyne/cm 
Density: 1.63 g/cm3 
Flash Point: 407.7°C
Enthalpy of  Vaporization: 114.8 kJ/mol 
Boiling Point: 750.6°C at 760 mmHg
Vapour Pressure: 1.14E-23 mmHg at 25°C 
The molecular structure of  Karminomycin with CAS NO.of  39472-31-6:

Karminomycin Uses

 Karminomycin (CAS NO.39472-31-6) is used as antineoplastic agent.

Karminomycin Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 2700ug/kg (2.7mg/kg)   Cancer Treatment Reports. Vol. 63, Pg. 899, 1979.
dog LDLo intravenous 600ug/kg (0.6mg/kg)   Cancer Treatment Reports. Vol. 63, Pg. 899, 1979.
human TDLo intravenous 12mg/kg/5D (12mg/kg) BEHAVIORAL: ANOREXIA (HUMAN

GASTROINTESTINAL: NAUSEA OR VOMITING

BLOOD: LEUKOPENIA
Cancer Treatment Reports. Vol. 61, Pg. 1705, 1977.
mammal (species unspecified) LD50 intraperitoneal 1300ug/kg (1.3mg/kg)   Antibiotiki. Vol. 29, Pg. 748, 1984.
man TDLo intravenous 1071ug/kg/17D (1.071mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

VASCULAR: THROMBOSIS DISTANT FROM INJECTION SITE

GASTROINTESTINAL: NAUSEA OR VOMITING
Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. Vol. 25(2), Pg. 63, 1979.
monkey LD50 oral 288mg/kg (288mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING
Drug and Chemical Toxicology. Vol. 4, Pg. 383, 1981.
mouse LD50 intraperitoneal 960ug/kg (0.96mg/kg)   Antibiotiki. Vol. 29, Pg. 437, 1984.
mouse LD50 intravenous 3200ug/kg (3.2mg/kg)   Antibiotiki. Vol. 23, Pg. 1005, 1978.
mouse LD50 oral 7300ug/kg (7.3mg/kg)   Cancer Treatment Reports. Vol. 61, Pg. 1705, 1977.
mouse LD50 subcutaneous 2500ug/kg (2.5mg/kg)   Antibiotiki. Vol. 21, Pg. 1030, 1976.
rat LD50 intraperitoneal 1550ug/kg (1.55mg/kg) LIVER: FATTY LIVER DEGERATION

LIVER: LIVER FUNCTION TESTS IMPAIRED

ENDOCRINE: OTHER CHANGES
Antibiotiki. Vol. 24, Pg. 218, 1979.
rat LD50 intravenous 1600ug/kg (1.6mg/kg)   Antibiotiki. Vol. 23, Pg. 1005, 1978.
rat LD50 oral 23mg/kg (23mg/kg)   Antibiotiki. Vol. 21, Pg. 904, 1976.
rat LD50 subcutaneous 4366ug/kg (4.366mg/kg)   Drug and Chemical Toxicology. Vol. 4, Pg. 383, 1981.

Karminomycin Safety Profile

Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects by intravenous route: anorexia, hallucinations and distorted perceptions, thrombosis, nausea or vomiting, fatty liver degeneration, impaired liver function, endocrine changes, and leukopenia (reduced white blood cell count). An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and fumes.

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