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Kepone

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Name

Kepone

EINECS 205-601-3
Annex I Index No: 606-019-00-6
CAS No. 143-50-0 Density 2.27g/cm3
Solubility

Stability

    Stable. Incompatible with strong oxidizing agents.

Toxicology

    Toxic if swallowed or absorbed through the skin. May act as a carcinogen.

    Toxicity data
    (

Melting Point 350oC (decomp)
Formula C10Cl10 O Boiling Point 459.7oC at 760 mmHg
Molecular Weight 490.60 Flash Point >100oC
Transport Information Appearance white powder
Safety Confirmed carcinogen with experimental carcinogenic data. Poison by ingestion, skin contact. Experimental teratogenic and reproductive effects. Mutation data reported. Inhalation, absorption, or ingestion by humans can lead to central nervous system, liver, and kidney damage, including bizarre symptoms caused by damage to the nervous system. Usually, the symptoms are tremors, ataxia, skin changes, hyperexcitability, hyperactivity, muscle spasms, testicular atrophy, low sperm count, estrogenic effects, sterility, breast enlargement, liver lesions, and cancer. An insecticide and fungicide. Registration suspended by the USEPA.

Analytical Methods:

   

For occupational chemical analysis use NIOSH: Kepone, 5508.

Risk Codes
Molecular Structure Molecular Structure of 143-50-0 (1,3,4-Metheno-2H-cyclobuta[cd]pentalen-2-one,1,1a,3,3a,4,5,5,5a,5b,6-decachlorooctahydro-) Hazard Symbols A carcinogen. Toxic by ingestion, inhalation, and skin absorption. Manufacture and use have been prohibited.
Synonyms

1,3,4-Metheno-2H-cyclobuta[cd]pentalen-2-one,decachlorooctahydro- (6CI);1,1a,3,3a,4,5,5,5a,5b,6-Decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalen-2-one;Chlordecone; Clordecone; Compound 1189; Decachloroketone;Decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalen-2-one;Decachloropentacyclo[5.2.1.02,6.03,9.05,8]decan-4-one; ENT-16391; GC 1189;Kepone; NSC 124074; NSC 56532

 

Kepone Chemical Properties

CAS: 143-50-0
EINECS: 205-601-3
Following is the Molecular Structure of  Kepone (143-50-0):

SMILES: ClC54C(=O)C1(Cl)C2(Cl)C5(Cl)C3(Cl)C4(Cl)C1(Cl)C2(Cl)C3(Cl)Cl
InChI: InChI=1/C10Cl10O/c11-2-1(21)3(12)6(15)4(2,13)8(17)5(2,14)7(3,16)9(6,18)10(8,19)20
InChIKey: LHHGDZSESBACKH-UHFFFAOYAM
Std.InChI: InChI=1S/C10Cl10O/c11-2-1(21)3(12)6(15)4(2,13)8(17)5(2,14)7(3,16)9(6,18)10(8,19)20
Std.InChIKey: LHHGDZSESBACKH-UHFFFAOYSA-N
Molecular Formula: C10Cl10O
Molecular Weight: 490.64
Boiling Point: 450.5℃ at 760mmHg
Flash Point: 189.8℃
Molar Volume: 215.6cm3
Density: 2.27g/cm3
Molar Refractivity: 86.66cm3
Surface Tension: 79.6dyne/cm
Polarizability: 34.35 10-24cm3
Enthalpy of Vaporization: 70.93kJ/mol
Vapour Pressure: 2.63E-08mmHg at 25℃

Kepone Uses

Used in the production of pesticide.

Kepone Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 250mg/kg (250mg/kg) BEHAVIORAL: TREMOR Toxicology and Applied Pharmacology. Vol. 45, Pg. 331, 1978.
mammal (species unspecified) LD50 unreported 126mg/kg (126mg/kg)   "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 65, 1971.
quail LD50 oral 237mg/kg (237mg/kg)   Journal of Reproduction and Fertility. Vol. 48, Pg. 371, 1976.
rabbit LD50 oral 65mg/kg (65mg/kg)   Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 642, 1966.
rabbit LD50 skin 345mg/kg (345mg/kg)   Guide to the Chemicals Used in Crop Protection. Vol. 6, Pg. 96, 1973.
rat LD50 oral 91300ug/kg (91.3mg/kg)   Neurobehavioral Toxicology and Teratology. Vol. 5, Pg. 91, 1983.
rat LD50 skin > 2gm/kg (2000mg/kg)   Toxicology and Applied Pharmacology. Vol. 14, Pg. 515, 1969.

Kepone Consensus Reports

NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7(1987),p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 20 (1979),p. 67.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 20 (1979),p. 67.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.

Kepone Safety Profile

Hazard Codes: T Toxic,  N Dangerous for the environment.
RIDADR: 2761
RTECS: PC8575000
HazardClass: 6.1(b)
PackingGroup: III
Risk Statements: 24/25-40-50/53
R24/25: Toxic in contact with skin and if swallowed.
R40: Limited evidence of a carcinogenic effect.
R50/53: Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements: 22-36/37-45-60-61
S22: Do not breathe dust.
S36/37: Wear suitable protective clothing and gloves.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible).
S60: This material and/or its container must be disposed of as hazardous waste.
S61: Avoid release to the environment. Refer to special instructions safety data sheet.
Confirmed carcinogen with experimental carcinogenic data. Poison by ingestion, skin contact. Experimental teratogenic and reproductive effects. Mutation data reported. Inhalation, absorption, or ingestion by humans can lead to central nervous system, liver, and kidney damage, including bizarre symptoms caused by damage to the nervous system. Usually, the symptoms are tremors, ataxia, skin changes, hyperexcitability, hyperactivity, muscle spasms, testicular atrophy, low sperm count, estrogenic effects, sterility, breast enlargement, liver lesions, and cancer. An insecticide and fungicide. Registration suspended by the USEPA.

Kepone Standards and Recommendations

DFG MAK: Confirmed Animal Carcinogen with Unknown Relevance to Humans
NIOSH REL: (Kepone) CL 0.001 mg/m3/15M

Kepone Analytical Methods

For occupational chemical analysis use NIOSH: Kepone, 5508.

Kepone Specification

 Kepone (143-50-0),which also can be called for 1,1a,3,3a,4,5,5,5a,5b,6-Decachlorooctahydro-1,3,4-metheno-2h-cyclobuta(cd)pe ; 1,1a,3,3a,4,5,5,5a,5b,6-Decachlorooctahydro-1,3,4-metheno-2H-cyclobuta(cd)pentalen-2-one ; 1,1a,3,3a,4,5,5,5a,5b,6-Decachloro-octahydro-1,3,4-metheno-2h-cyclobuta[cd]pen ; 1,2,3,4,5,5,6,7,8,9,10,10-Dodecachlorooctahydro-1,3,4-metheno-2-cyclobuta-(c,d) ; 1,2,3,5,6,7,8,9,10,10-Decachloro(5.2.1.0(sup2,6).0(sup3,9).0(sup5,8))decan ; 1,2,3,5,6,7,8,9,10,10-Decachloro(5.2.1.02,6.03,9 .05,8)decan-4-one ; 1,3,4-Metheno-2H-cyclobuta(cd)pentalen-2-one, 1,1a,3,3a,4,5,5,5a,5b,6-decachloroctahydro- ; 1,3,4-Metheno-2h-cyclobuta(cd)pentalen-2-one,1,1a,3,3a,4,5,5,5a,5b,6-decachlor . Kepone (143-50-0) is an odorless colorless crystalline solid and it should be stored at 0℃-6℃. It's insoluble in water.

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