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L-Lactide

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Name

L-Lactide

EINECS 224-832-0
CAS No. 4511-42-6 Density 1.186 g/cm3
PSA 52.60000 LogP -0.13660
Solubility 16.7g/L at 20℃ Melting Point 92-94 °C(lit.)
Formula C6H8O4 Boiling Point 285.5 °C at 760 mmHg
Molecular Weight 144.127 Flash Point 150.6 °C
Transport Information N/A Appearance Crystalline flake object
Safety 26-37/39 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 4511-42-6 (L-Lactide) Hazard Symbols IrritantXi
Synonyms

1,4-Dioxane-2,5-dione,3,6-dimethyl-, (3S-cis)-;p-Dioxane-2,5-dione, 3,6-dimethyl-, L- (8CI);(-)-L-Dilactide;(3S,6S)-3,6-Dimethyl-1,4-dioxane-2,5-dione;(S,S)-3,6-Dimethyl-1,4-dioxane-2,5-dione;1,4-Dioxane-2,5-dione, 3,6-dimethyl-,(3S,5S)-;L,L-Dilactide;L-(-)-Lactide;L-Dilactide;Purasorb L;

Article Data 36

L-Lactide Synthetic route

Reaxys ID: 11369849

Reaxys ID: 11369849

4511-42-6

L,L-dilactide

Conditions
ConditionsYield
at 60 - 320℃; for 0.35 - 0.433333h; Product distribution / selectivity; Pyrolysis;100%
at 280℃; for 2h; Product distribution / selectivity; Pyrolysis;95.3%
Reaxys ID: 11385251

Reaxys ID: 11385251

4511-42-6

L,L-dilactide

Conditions
ConditionsYield
tin octylate at 200℃; under 5 Torr; Product distribution / selectivity;99.3%
at 200℃; under 5 Torr; Product distribution / selectivity;99.3%
at 200℃; under 5 Torr; Product distribution / selectivity;
at 200℃; under 5 Torr; Product distribution / selectivity;
at 210℃; under 4 Torr; Product distribution / selectivity;

stannous lactate

4511-42-6

L,L-dilactide

Conditions
ConditionsYield
With benzylurea at 100 - 180℃; under 1 Torr; for 2h; Temperature; Reagent/catalyst; Pressure;96.72%
79-33-4

L-Lactic acid

4511-42-6

L,L-dilactide

Conditions
ConditionsYield
In water at 240℃; under 760.051 Torr; Inert atmosphere; Autoclave;94%
Stage #1: L-Lactic acid With 1-docosanol; 3-chloropyridinium trifluoromethanesulfonate at 140℃; under 25 Torr; for 12h;
Stage #2: at 160℃; under 1 Torr; for 3h; Reagent/catalyst; Pressure; Temperature; Time;
80%
Stage #1: L-Lactic acid With 1-docosanol; 3-chloropyridinium trifluoromethanesulfonate In water at 140℃; under 30.003 Torr; for 12h;
Stage #2: In water at 160℃; under 0.99985 Torr; for 3h; Reagent/catalyst;
79%
687-47-8

(S)-Ethyl lactate

4511-42-6

L,L-dilactide

Conditions
ConditionsYield
titanium(IV) tetraethanolate; Triethylene glycol dimethyl ether at 120℃; under 50 Torr; for 7.5h; Inert atmosphere;85.5%
Stage #1: (S)-Ethyl lactate With cerium(III) chloride heptahydrate In water Inert atmosphere;
Stage #2: for 4h; Reagent/catalyst;
52%
With Triethylene glycol dimethyl ether; titanium(IV) tetraethanolate at 120℃; for 6h; Product distribution / selectivity;
79-33-4

L-Lactic acid

661-19-8

1-docosanol

A

908335-80-8

2-docosene

B

methyl 2-docosyloxypropionate

C

4511-42-6

L,L-dilactide

Conditions
ConditionsYield
Stage #1: L-Lactic acid; 1-docosanol With 3-chloropyridinium trifluoromethanesulfonate at 140℃; under 25 Torr; for 12h;
Stage #2: at 160℃; under 1 Torr; for 3h;
Stage #3: With methanol; potassium carbonate Reagent/catalyst; Pressure; Temperature; Time;
A n/a
B n/a
C 80%
79-33-4

L-Lactic acid

2216-51-5

(-)-menthol

A

923031-01-0

L-menthyl L-lactoyl L-lactate

B

923031-02-1

L-menthyl L-lactoyl L-lactoyl L-lactate

C

61597-98-6

(1R,2S,5R)-menthyl (S)-(-)-lactate

D

4511-42-6

L,L-dilactide

Conditions
ConditionsYield
In n-heptane; water at 128℃; for 32h; Product distribution / selectivity; Heating / reflux;A 24.6%
B 0.4%
C 67.7%
D 0.6%
sulfuric acid In n-heptane at 119℃; for 2h; Product distribution / selectivity;A 32.2%
B 1.9%
C 57.6%
D 0.4%
sodium hydrogen sulfate In n-heptane at 93 - 123℃; for 17h; Product distribution / selectivity; Heating / reflux;A 36.5%
B 5.6%
C 48.7%
D 4.8%
Reaxys ID: 11369848

Reaxys ID: 11369848

A

hexalactide

B

859046-55-2

trilactide

C

C12H16O8

D

859046-57-4

C15H20O10

E

C21H28O14

F

13076-19-2

(3R,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione

G

4511-42-6

L,L-dilactide

H

13076-17-0

D-lactide

Conditions
ConditionsYield
at 60 - 400℃; for 0.566667h; Product distribution / selectivity; Pyrolysis;A 4.51%
B 3.26%
C 5.59%
D 6.02%
E 1.88%
F 18.28%
G n/a
H n/a
Reaxys ID: 11369849

Reaxys ID: 11369849

A

hexalactide

B

859046-55-2

trilactide

C

C12H16O8

D

859046-57-4

C15H20O10

E

13076-19-2

(3R,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione

F

4511-42-6

L,L-dilactide

G

13076-17-0

D-lactide

Conditions
ConditionsYield
at 60 - 400℃; for 0.566667h; Product distribution / selectivity; Pyrolysis;A 0.46%
B 0.5%
C 1.65%
D 0.75%
E 12.17%
F n/a
G n/a
547-64-8

methyl lactate

A

67-56-1

methanol

B

DP2

DP2

C

DP3

DP3

D

DP4

DP4

E

4511-42-6

L,L-dilactide

Conditions
ConditionsYield
Amberlys 36 resin at 104 - 115℃; under 25 - 80 Torr; for 28h; Heating / reflux;A n/a
B 7.4%
C 0.3%
D 0%
E 0%

L-Lactide Specification

The CAS registry number of 1,4-Dioxane-2,5-dione,3,6-dimethyl-,(3S,6S)- is 4511-42-6. The systematic name is (3S,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione. Its EINECS registry number is 224-832-0. In addition, the molecular formula is C6H8O4 and the molecular weight is 144.13. It belongs to the classes of Chiral Building Blocks; Dioxanes; Dioxanes Dioxolanes; Functional Materials; Glycidyl Compounds; Lactones Lactides (for High-Performance Polymer Research); Reagent for High-Performance Polymer Research; Synthetic Organic Chemistry. And it should be stored in a cool and dry place.

Physical properties about 1,4-Dioxane-2,5-dione,3,6-dimethyl-,(3S,6S)- are: (1)ACD/BCF (pH 5.5): 1; (2)ACD/BCF (pH 7.4): 1; (3)ACD/KOC (pH 5.5): 4.003; (4)ACD/KOC (pH 7.4): 4.003; (5)#H bond acceptors: 4; (6)Polar Surface Area: 52.6 Å2; (7)Index of Refraction: 1.429; (8)Molar Refractivity: 31.335 cm3; (9)Molar Volume: 121.519 cm3; (10)Polarizability: 12.422 ×10-24cm3; (11)Surface Tension: 31.383 dyne/cm; (12)Density: 1.186 g/cm3; (13)Flash Point: 150.578 °C; (14)Enthalpy of Vaporization: 52.452 kJ/mol; (15)Boiling Point: 285.469 °C at 760 mmHg; (16)Vapour Pressure: 0.003 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
It is irritating to eyes, respiratory system and skin. When you are using it, wear suitable protective clothing and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: C[C@H]1C(=O)O[C@H](C(=O)O1)C
(2)InChI: InChI=1/C6H8O4/c1-3-5(7)10-4(2)6(8)9-3/h3-4H,1-2H3/t3-,4-/m0/s1
(3)InChIKey: JJTUDXZGHPGLLC-IMJSIDKUBG

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