- Lincomycin
- Lincomycin A
- Lincomycin hydrochloride
- Lincomycin hydrochloride monohydrate
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| Name |
Lincomycin hydrochloride monohydrate |
EINECS | 212-726-7 |
| CAS No. | 7179-49-9 | Density | N/A |
| PSA | 157.02000 | LogP | 0.20950 |
| Solubility | N/A | Melting Point |
156-158° |
| Formula | C18H34N2O6S.HCl.H2O | Boiling Point | 646.8 °C at 760 mmHg |
| Molecular Weight | 461.01 | Flash Point | 345 °C |
| Transport Information | N/A | Appearance | White powder |
| Safety | 26 | Risk Codes | 36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 Xi
|
| Synonyms |
D-erythro-D-galacto-Octopyranoside,methyl 6,8-dideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-,monohydrochloride, monohydrate, trans-a- (8CI);D-erythro-a-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-,monohydrochloride, monohydrate, (2S-trans)-;Methyl 6,8-dideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-D-erythro-alpha-D-galacto-octopyranoside monohydrochloride monohydrate;Lincomycin, hydrochloride hydrate;Lincomycin HCL; |
Lincomycin hydrochloride monohydrate Chemical Properties
IUPAC Name: (2S,4R)-N-[(1R,2R)-2-Hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide hydrate hydrochloride
Synonyms of Lincomycin, hydrochloride hydrate (CAS NO.7179-49-9): Lincomycin hydrochloride [USAN:JAN] ; CCRIS 9080 ; Lincocin ; Lincomix ; Lincomycin HCl ; Lincomycin hydrochloride ; Lincomycin hydrochloride monohydrate ; Lincomycin soluble ; Lincomycin, hydrochloride hydrate ; Methyl 6,8-dideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-D-erythro-alpha-D-galacto-octopyranoside monohydrochloride monohydrate ; NSC 70731 ; UNII-M6T05Z2B68 ; D-erythro-D-galacto-Octapyranoside, methyl 6,8-dideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-, monohydrochloride, monohydrate, trans-alpha- ; D-erythro-alpha-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(((1-methyl-4-propyl-2-pyrrolidinyl)carbonyl)amino)-1-thio-, monohydrochloride, monohydrate, (2S-trans)-
CAS NO: 7179-49-9
Classification Code: Antibacterial ; Drug / Therapeutic Agent ; Human Data
Molecular Formula of Lincomycin, hydrochloride hydrate (CAS NO.7179-49-9): C18H37ClN2O7S
Molecular Weight: 461.0136
Molecular Structure:
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Appearance:White powder
storage temp:2-8°C
Merck:5500
Polar Surface Area: 95 Å2
Flash Point: 345 °C
Enthalpy of Vaporization: 109.25 kJ/mol
Boiling Point of Lincomycin, hydrochloride hydrate (CAS NO.7179-49-9): 646.8 °C at 760 mmHg
Vapour Pressure: 1.85E-19 mmHg at 25°C
Lincomycin hydrochloride monohydrate Uses
Lincomycin, hydrochloride hydrate (CAS NO.7179-49-9) has a strong antibacterial effect ,which is similar to the Gram-positive bacteria.
Lincomycin hydrochloride monohydrate Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 1gm/kg (1000mg/kg) | "Compounds Available for Fundamental Research, Volume II-6, Antibiotics, A Program of Upjohn Company Research Laboratory." Vol. 2(6), Pg. -, 1971. | |
| mouse | LD50 | intravenous | 214mg/kg (214mg/kg) | Drugs in Japan Vol. 6, Pg. 891, 1982. | |
| rat | LD50 | intravenous | 342mg/kg (342mg/kg) | Drugs in Japan Vol. 6, Pg. 891, 1982. | |
| rat | LD50 | oral | > 4gm/kg (4000mg/kg) | "Compounds Available for Fundamental Research, Volume II-6, Antibiotics, A Program of Upjohn Company Research Laboratory." Vol. 2(6), Pg. -, 1971. | |
| rat | LD50 | subcutaneous | 9778mg/kg (9778mg/kg) | "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 65, 1969. | |
| women | TDLo | oral | 192mg/kg/8D-I (192mg/kg) | BLOOD: NORMOCYTIC ANEMIA | Postgraduate Medical Journal. Vol. 59, Pg. 796, 1983. |
Lincomycin hydrochloride monohydrate Safety Profile
Hazard Codes: 
Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RTECS: RH6315500
Poison by intravenous route. Moderately toxic by intraperitoneal route. Used as an antibacterial agent. When heated to decomposition it emits toxic fumes of SOx, NOx, and HCl.
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