IUPAC Name: (2S)-N-[(2S,4S,5S)-5-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide
Formula: C₃₇H₄₈N₄O₅
Molecular Weight: 628.8 g/mol
Molecular Structure of Lopinavir (CAS NO.192725-17-0):

Melting Point: 124-127 °C 
Flash Point: 512.7 °C 
Boiling Point: 924.1 °C at 760 mmHg 
Density: 1.163 g/cm³ 
Enthalpy of  Vaporization: 140.81 kJ/mol 
Appearance: white crystalline solid
Index of Refraction: 1.577 
Molar Refractivity: 179.17 cm³ 
Molar Volume: 540.4 cm³ 
Surface Tension: 49.4 dyne/cm 
XLogP3-AA: 5.9
H-Bond Donor: 4
H-Bond Acceptor: 5
Rotatable Bond Count: 15
Tautomer Count: 8
Exact Mass: 628.362471
MonoIsotopic Mass: 628.362471
Topological Polar Surface Area: 120
Heavy Atom Count: 46 
Product Categories: Anti-viral Compounds;Anti-virals;Intermediates & Fine Chemicals;Non-nucleoside Reverse Transcriptase;Pharmaceuticals

In an attempt to improve on the HIV resistance and serum protein-binding properties of the company's earlier protease inhibitor, ritonavir, Lopinavir was developed by Abbott. Abbott pursued a strategy of co-administering lopinavir with sub-therapeutic doses of ritonavir, and lopinavir is only marketed as a co-formulation with ritonavir. It is the first multi-drug capsule to contain a drug not available individually. Lopinavir/ritonavir was approved by the US FDA on 15 September 2000, and in Europe in April 2001. On June 26, 2016, Its patent will expire in the US. Abbott Laboratories was one of the earliest users of the Advanced Photon Source, a national synchrotron-radiation light source at Argonne National Laboratory. One of the early research projects undertaken at the Advanced Photon Source was the Human Immunodeficiency Virus. Using X-ray crystallography, researchers found the points of attack of the HIV protease inhibitors–agents that block the breakdown of proteins. Protease inhibitors stop HIV from making new copies of itself by blocking the last step in the process, when the virus attempts to replicate - and out of that discovery came the drug Kaletra.

 Lopinavir (CAS NO.192725-17-0) is used as a selective HIV protease inhibitor.  It is also used as an analogue of Ritonavir.

 The chemical synonyms of Lopinavir (CAS NO.192725-17-0) is also named as (1S-(1R*(R*),3R*,4R*))-N-(4-(((2,6-Dimethylphenoxy)acetyl)amino)-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl)tetrahydro-alpha-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide ; (alphaS)-Tetrahydro-N-((alphaS)-alpha-((2S,3S)-2-hydroxy-4-phenyl-3-(2-(2,6-xylyloxy)acetamido)butyl)phenethyl)-alpha-isopropyl-2-oxo-1(2H)-pyrimidineacetamide ; A 157378.0 ; ABT 378 ; ABT-378 ; UNII-2494G1JF75 .