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84994-24-1

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Basic Information
CAS No.: 84994-24-1
Name: MAEM
Molecular Structure:
Molecular Structure of 84994-24-1 (MAEM)
Formula: C13H10 N4 O3 S2
Molecular Weight: 350.44
Synonyms: 4-Thiazoleaceticacid, 2-amino-a-(methoxyimino)-,2-benzothiazolyl ester, (Z)-;(Z)-2-[Methoxyimino]-2-(2-aminothiazol-4-yl)acetic acid;(Z)-2-[Methoxyimino]-2-(2-aminothiazol-4-yl)acetic acid 2-benzothiazole ester
EINECS: 279-540-6
Density: 1.63g/cm3
Boiling Point: 563.2°C at 760 mmHg
Flash Point: 294.4°C
Hazard Symbols: R36/37/38:;
Risk Codes:  Xi:Irritant;
">  Xi:Irritant;
PSA: 171.19000
LogP: 3.67310
Synthetic route
84994-24-1

2-methoxyimino-2-(2-aminothiazol-4-yl)acetic acid S-2-benzothiazole ester

7-amino-3-[2-(5-methyl-2H-tetrazolyl)methyl]cephalosporanic acid

82547-58-8

cefteram

Conditions
ConditionsYield
With sodium metabisulfite; triethylamine In methanol; dichloromethane at 0℃; for 3h;89.1%

7-amino-3-[2-(4-methyl-5-thiazolyl)vinyl]-3-cephem-4-carboxylic acid

7-amino-3-[(E)-2-(4-methyl-5-thiazolyl)vinyl]-3-cephem-4-carboxylic acid

84994-24-1

2-methoxyimino-2-(2-aminothiazol-4-yl)acetic acid S-2-benzothiazole ester

A

104146-53-4

7-<(Z)-2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetamido>-3(Z)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylic acid sodium salt

B

104146-16-9

7-<(Z)-2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetamido>-3(E)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylic acid sodium salt

Conditions
ConditionsYield
Stage #1: 7-amino-3-[2-(4-methyl-5-thiazolyl)vinyl]-3-cephem-4-carboxylic acid; 7-amino-3-[(E)-2-(4-methyl-5-thiazolyl)vinyl]-3-cephem-4-carboxylic acid; 2-methoxyimino-2-(2-aminothiazol-4-yl)acetic acid S-2-benzothiazole ester With triethylamine In water; acetone at 0 - 15℃; for 3 - 4h;
Stage #2: With sodium 2-ethylhexanoic acid In water; acetone at 20 - 25℃; for 1h; Product distribution / selectivity;
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    Specifications CAS No.: 84994-24-1 Other Names: MAEM MF: MAEM EINECS No.: MAEM Place of Origin: Anhui, China (Mainland) Type: Anesthetic Agents, Anti-Allergic Agents, Antibiotic and Antimicrobial Agents, Antidote, Antineoplastic Agents, A

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    MAEM

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    84994-24-1

    MAEM

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Chemistry

Product Name: Maem
Synonyms : Benzothiazol-2-yl (Z)-2-methoxyimino-2-(2-aminothiazole-4-yl)thioacetate
Molecular Structure of  Maem (CAS NO. 84994-24-1) :
Molecular Formula of  Maem (CAS NO. 84994-24-1) : C13H10N4O2S3
Molecular Weight of  Maem (CAS NO. 84994-24-1) : 350.44
CAS NO: 84994-24-1
Product Categories: Amines;Cefotaxime;Ceftriaxone
Mol File: 84994-24-1.mol
Appearance:  Maem (CAS NO. 84994-24-1) is white or light yellow crystalline powder.

Uses

  Maem (CAS NO. 84994-24-1) is intermediates of Cephalosporins antibiotics drugs , and raw materials in the production of ceftriaxone, cefotaxime sodium and other drug.

Production

 Maem (CAS NO. 84994-24-1) can be obtained ,with AT, M as raw materials and cyclohexyl carbodiimide and pyridine as the catalyst.