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Name	Melphalan hydrochloride	EINECS	N/A
CAS No.	3223-07-2	Density	g/cm³
PSA	66.56000	LogP	3.42730
Solubility	N/A	Melting Point	175-178 °C
Formula	C13H18 Cl2 N2 O2 . Cl H	Boiling Point	473.1°Cat760mmHg
Molecular Weight	341.665	Flash Point	239.9°C
Transport Information	N/A	Appearance	N/A
Safety	Deadly poison by intravenous route. Human systemic effects by ingestion: nausea and vomiting. Questionable carcinogen with experimental carcinogenic data. When heated to decomposition it emits very toxic fumes of Cl⁻, NO_x, and HCl.	Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	Alanine,3-[p-[bis(2-chloroethyl)amino]phenyl]-, monohydrochloride, L- (8CI); L-Phenylalanine,4-[bis(2-chloroethyl)amino]-, monohydrochloride (9CI); Melphalan hydrochloride

Melphalan hydrochloride Chemical Properties

IUPAC: 2-Amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid hydrochloride
L-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine monohydrochloride CAS NO.of 3223-07-2 is also called for AI3-26377 ; Alanine nitrogen mustard hydrochloride ; Alkeran ; Alkeran hydrochloride ; CB 3025 hydrochloride ; L-Phenylalanine mustard hydrochloride ; L-Sarcolysine hydrochloride ; Melfalan hydrochloride ; Melphalan HCl ; Melphalan hydrochloride ; Phenylalanine mustard hydrochloride ; SK 15673 ; UNII-1VXP4V453T and so on.
CAS: 3223-07-2
Molecula Formula: C₁₃H₁₉Cl₃N₂O₂
Molecular Weight: 341.66
EINECS: 205-726-3
ACD/LogP: 1.80
ACD/LogD (pH 5.5): -0.72
ACD/LogD (pH 7.4): -0.71
ACD/BCF (pH 5.5): 1
ACD/BCF (pH 7.4): 1
ACD/KOC (pH 5.5): 1
ACD/KOC (pH 7.4): 1
H bond acceptors: 4
H bond donors: 3
Freely Rotating Bonds: 9
Heavy Atom Count: 20
Formal Charge: 0
Complexity: 265
Isotope Atom Count: 0
Defined Atom StereoCenter Count: 0
Undefined Atom StereoCenter Count: 1
Defined Bond StereoCenter Count: 0
Undefined Bond StereoCenter Count: 0
Covalently-Bonded Unit Count: 2
Flash Point: 239.9°C
Enthalpy of Vaporization: 77.55 kJ/mol
Boiling Point: 473.1°C at 760 mmHg
Vapour Pressure: 9.33E-10 mmHg at 25°C
The molecular structure of L-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine monohydrochloride CAS NO.of 3223-07-2:

Melphalan hydrochloride Uses

L-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine monohydrochloride (CAS NO.3223-07-2) is used as antineoplastic agent and myeloablative agonist.

Melphalan hydrochloride Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	intravenous	430ug/kg (0.43mg/kg)	BLOOD: LEUKOPENIA BLOOD: THROMBOCYTOPENIA BLOOD: OTHER CHANGES	Cancer Chemotherapy Reports, Part 2. Vol. 2, Pg. 201, 1965.
dog	LDLo	oral	4mg/kg (4mg/kg)	BLOOD: AGRANULOCYTOSIS BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE	National Technical Information Service. Vol. PB229-000,
human	TDLo	oral	1200ug/kg/5D- (1.2mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING	Cancer Chemotherapy Reports, Part 1. Vol. 57, Pg. 369, 1973.
monkey	LDLo	intravenous	430ug/kg (0.43mg/kg)	BLOOD: LEUKOPENIA BLOOD: AGRANULOCYTOSIS BLOOD: OTHER CHANGES	Cancer Chemotherapy Reports, Part 2. Vol. 2, Pg. 201, 1965.
mouse	LD50	intravenous	23mg/kg (23mg/kg)		National Technical Information Service. Vol. PB84-162486,

Melphalan hydrochloride Safety Profile

Deadly poison by intravenous route. Human systemic effects by ingestion: nausea and vomiting. Questionable carcinogen with experimental carcinogenic data. When heated to decomposition it emits very toxic fumes of Cl⁻, NO_x, and HCl.

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