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Basic Information
| CAS No.: | 72-43-5 |
|---|---|
| Name: | 2,2-Bis(p-methoxyphenol)-1,1,1 -trich loroethane |
| Molecular Structure: | |
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| Formula: | C16H15 Cl3 O2 |
| Molecular Weight: | 345.653 |
| Synonyms: | Ethane,1,1,1-trichloro-2,2-bis(p-methoxyphenyl)- (8CI);1,1,1-Trichloro-2,2-bis(4-methoxyphenyl)ethane;1,1,1-Trichloro-2,2-bis(p-methoxyphenyl)ethane;1,1,1-Trichloro-2,2-di(4-methoxyphenyl)ethane;1,1-Bis(p-methoxyphenyl)-2,2,2-trichloroethane;2,2,2-Trichloro-1,1-bis(4-methoxyphenyl)ethane;2,2-Bis(4-methoxyphenyl)-1,1,1-trichloroethane; 2,2-Bis(p-methoxyphenyl)-1,1,1-trichloroethane;2,2-Di-p-anisyl-1,1,1-trichloroethane;4,4'-(2,2,2-Trichloroethylidene)dianisole; DMDT;Di(p-methoxyphenyl)(trichloromethyl)methane; Dimethoxy-DDT; Marlate; Mesox K;Methoxcide; Methoxy-DDT; Methoxychlor; Metox; Metox plynny; Mezox K; NSC 8945;p,p'-DMDT; p,p'-Dimethoxydiphenyltrichloroethane; p,p'-Methoxychlor |
| EINECS: | 200-779-9 |
| Density: | 1.4 g/cm3 |
| Melting Point: | 86-88 °C(lit.) |
| Boiling Point: | greater than or equal to 100 °C. |
| Flash Point: | less than 60 degrees C |
| Solubility: | In water, 0.1 mg/l @ 25 deg C |
| Appearance: | COLOURLESS TO LIGHT YELLOW CRYSTALS , WITH CHARACTERISTIC ODOUR. |
| Hazard Symbols: | Toxic material. TLV: TWA 10 mg/m3; not classifiable as a human carcinogen. |
| Risk Codes: | 20/21/22-40 |
| Safety: | Suspected carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Moderately toxic by intraperitoneal and skin contact routes. Human systemic effects by skin contact: somnolence. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits highly toxic fumes of Cl−. See also DDT and CHLOROPHENOLS. |
| PSA: | 18.46000 |
| LogP: | 5.20590 |
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2,2-Bis(p-methoxyphenol)-1,1,1 -trich loroethane
Chemistry
Other names:Methoxcide,Dimethoxy-DDT,Methoxy-DDT
Molecular formula:C16H15Cl3O2
Molar mass:345.65 g mol-1
Melting point:87 °C, 360 K, 189 °F
Boiling point:decomposes
Molecular formula:C16H15Cl3O2
Molar mass:345.65 g mol-1
Melting point:87 °C, 360 K, 189 °F
Boiling point:decomposes
Uses
Methoxychlor is a synthetic organochlorine used as an insecticide.
Toxicity Data With Reference
| 1. | spm-rat-orl 28 g/kg/10W-C | PSEBAA Proceedings of the Society for Experimental Biology and Medicine. 176 (1984),187. | ||
| 2. | cyt-ham-ipr 50 mg/kg | ARTODN Archives of Toxicology. 58 (1985),152. | ||
| 3. | orl-rat TDLo:18,200 mg/kg/2Y-C:CAR,TER | EVHPAZ EHP, Environmental Health Perspectives. Subseries of DHEW Publications. 36 (1980),205. | ||
| 4. | orl-mus TDLo:56,700 mg/kg/90W-C:CAR,TER | JCROD7 Journal of Cancer Research and Clinical Oncology. 93 (1979),173. | ||
| 5. | orl-rat TD:80 g/kg/2Y-C:CAR,TER | LIFSAK Life Sciences. 24 (1979),1367. | ||
| 6. | orl-rat TD:72,800 mg/kg/2Y-C:CAR | EVHPAZ EHP, Environmental Health Perspectives. Subseries of DHEW Publications. 36 (1980),205. | ||
| 7. | orl-hmn LDLo:6430 mg/kg | PCOC** Pesticide Chemicals Official Compendium ,Association of the American Pesticide Control Officials, Inc.(Topeka, KS.: )1966,705. | ||
| 8. | skn-hmn TDLo:2414 mg/kg:CNS | PCOC** Pesticide Chemicals Official Compendium ,Association of the American Pesticide Control Officials, Inc.(Topeka, KS.: )1966,705. | ||
| 9. | orl-rat LD50:5000 mg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 99 (1950),140. | ||
| 10. |
Consensus Reports
IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal No Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 20 ,1979,p. 259.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 5 ,1974,p. 193.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Bioassay (feed); No Evidence: mouse, rat NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-35 ,1978. . EPA Genetic Toxicology Program. Community Right-To-Know List.
Safety Profile
Suspected carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Moderately toxic by intraperitoneal and skin contact routes. Human systemic effects by skin contact: somnolence. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits highly toxic fumes of Cl−. See also DDT and CHLOROPHENOLS.
Standards and Recommendations
OSHA PEL: TWA Total Dust: 10 mg/m3; 5 mg/m3
ACGIH TLV: TWA 10 mg/m3; Not Classifiable as a Human Carcinogen
DFG MAK: 15 mg/m3
ACGIH TLV: TWA 10 mg/m3; Not Classifiable as a Human Carcinogen
DFG MAK: 15 mg/m3