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| CAS No.: | 135-07-9 |
|---|---|
| Name: | Methyclothiazide |
| Molecular Structure: | |
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| Formula: | C9H11Cl2N3O4S2 |
| Molecular Weight: | 360.242 |
| Synonyms: | 6-Chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2H-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxide;6-Chloro-3-chloromethyl-2-methyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dioxide;6-Chloro-3-chloromethyl-3,4-dihydro-2-methyl-7-sulfamoyl-1,2,4-benzothiadiazine1,1-dioxide;6-Chloro-3-chloromethyl-3,4-dihydro-2-methyl-7-sulfamoyl-2H-1,2,4-benzothiadiazine1,1-dioxide;Aquatensen;Ciba 7272-Su;Duretic;Enduron;Enduronum;Eutron;Methyclothiazid;Methyclothiazide;Methycyclothiazide;Methylcyclothiazide;NSC110431;Naturon; |
| EINECS: | 205-172-2 |
| Density: | 1.613 g/cm3 |
| Melting Point: | 223-225oC |
| Boiling Point: | 597.928 °C at 760 mmHg |
| Flash Point: | 315.416 °C |
| Solubility: | 50mg/L(room temperature) |
| Appearance: | white crystal powder |
| PSA: | 126.33000 |
| LogP: | 3.53610 |
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Chemistry
Product Name: Methylcyclothiazide (CAS NO.135-07-9)
Molecular Formula: C9H11Cl2N3O4S2
Molecular Weight: 360.24g/mol
Mol File: 135-07-9.mol
Einecs: 205-172-2
Appearance: White crystal powder
Melting Point: 223-225°C
Boiling point: 597.9 °C at 760 mmHg
Flash Point: 315.4 °C
Density: 1.613 g/cm3
Solubility: Easily soluble in acetone
Surface Tension: 55.1 dyne/cm
Enthalpy of Vaporization: 89.05 kJ/mol
Vapour Pressure: 2.93E-14 mmHg at 25°C
XLogP3: 1.4
H-Bond Donor: 2
H-Bond Acceptor: 7
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 870mg/kg (870mg/kg) | "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 77, 1969. | |
| mouse | LD50 | intravenous | 400mg/kg (400mg/kg) | "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 77, 1969. | |
| mouse | LD50 | oral | > 10gm/kg (10000mg/kg) | Drugs in Japan Vol. 6, Pg. 825, 1982. | |
| rat | LD50 | intraperitoneal | 2gm/kg (2000mg/kg) | "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 77, 1969. | |
| rat | LD50 | oral | > 4gm/kg (4000mg/kg) | Drugs in Japan Vol. 6, Pg. 825, 1982. |
Safety Profile
Poison by intravenous route. Moderately toxic by intraperitoneal route. Mutation data reported. An FDA proprietary drug. When heated to decomposition it emits very toxic fumes of SOx, NOx, and Cl−.
Specification
Methylcyclothiazide ,its CAS NO. is 135-07-9,the synonyms is 2-Methyl-,1,1-dioxide ; 4-Benzothiadiazine-7-sulfonamide,6-chloro-3-(chloromethyl)-3,4-dihydro-2h-2 ; 6-Chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2h-1,2,4-benzothiadiazine-7-sul ; 6-Chloro-3-chloromethyl-2-methyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine ; 6-Chloro-3-chloromethyl-3,4-dihydro-2-methyl-7-sulfamoyl-1,2,4-benzothiadiazin ; Aquatensen;ciba7272-su ; Duretic .