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Metolazone

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Name

Metolazone

EINECS 241-539-3
CAS No. 17560-51-9 Density 1.4 g/cm3
PSA 100.88000 LogP 4.69820
Solubility 60.3mg/L(25 oC) Melting Point 252-254°C
Formula C16H16ClN3O3S Boiling Point 613.6 °C at 760 mmHg
Molecular Weight 365.84 Flash Point 324.9 °C
Transport Information N/A Appearance Crystalline solid
Safety Risk Codes N/A
Molecular Structure Molecular Structure of 17560-51-9 (Metolazone) Hazard Symbols N/A
Synonyms

Metenix;Diulo;6-Quinazolinesulfonamide,7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl- (8CI);2-Methyl-3-(o-tolyl)-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone;Metozalone;Mykrox;Normelan;Oldren;SR 720-22;Xuret;Zaroxolyn;

 

Metolazone Chemical Properties

Molecular Structure:

Molecular Formula: C16H16ClN3O3S
Molecular Weight: 365.8345
IUPAC Name: 7-Chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2-dihydroquinazoline-6-sulfonamide
Synonyms of Zaroxolyn (CAS NO.17560-51-9): 2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone ; 5-25-09-00212 (Beilstein Handbook Reference) ; 6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo- ; 6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl- ; 7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide ; 7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide ; BRN 0965506 ; Diulo ; EINECS 241-539-3 ; HSDB 3367 ; Metalozone ; Metenix ; Metolazona ;  Metolazone ; Metolazonum ; Metolazonum [INN-Latin] ; Microx ; Mykrox ; Oldren ; SR 720-22 ; UNII-TZ7V40X7VX
CAS NO: 17560-51-9
Classification Code: Antihypertensive ; Antihypertensive agents ; Cardiovascular Agents ; Diuretic ; Diuretics ; Drug / Therapeutic Agent ; Human Data ; Natriuretic Agents ; Reproductive Effect
Melting point: 252-254°C 
Index of Refraction: 1.629
Molar Refractivity: 92.81 cm3
Molar Volume: 261.2 cm3
Surface Tension: 53.7 dyne/cm
Density: 1.4 g/cm3
Flash Point: 324.9 °C
Enthalpy of Vaporization: 91.06 kJ/mol
Boiling Point: 613.6 °C at 760 mmHg
Vapour Pressure: 5.43E-15 mmHg at 25°C

Metolazone Uses

  Zaroxolyn (CAS NO.17560-51-9) is used as a diruetic and an antihypertensive.

Metolazone Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 2mg/kg/2W-I (2mg/kg) VASCULAR: STRICTIRA; CJAMGES OM VESSE;S Postgraduate Medical Journal. Vol. 67, Pg. 860, 1991.
mouse LD50 intraperitoneal > 1500mg/kg (1500mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) United States Patent Document. Vol. #3360518,
mouse LD50 oral > 5gm/kg (5000mg/kg)   United States Patent Document. Vol. #3360518,
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 261, 1982.
rat LD50 intraperitoneal > 5gm/kg (5000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 261, 1982.
rat LD50 oral > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. 6, Pg. APP-20, 1982.
rat LD50 subcutaneous > 5gm/kg (5000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 261, 1982.
women TDLo oral 150ug/kg (0.15mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
British Medical Journal. Vol. 1, Pg. 1381, 1976.

Metolazone Safety Profile

Human systemic effects by ingestion: general anesthesia, convulsions, and muscle contractions. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits Cl, SOx, and NOx
RTECS of Zaroxolyn (CAS NO.17560-51-9): VA1700000

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