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| CAS No.: | 140-31-8 |
|---|---|
| Name: | N-Aminoethylpiperazine |
| Molecular Structure: | |
|
|
|
| Formula: | C6H15N3 |
| Molecular Weight: | 129.205 |
| Synonyms: | Piperazine,1-(2-aminoethyl)- (6CI,7CI,8CI);1-(2-Aminoethyl)piperazine;1-(b-Aminoethyl)piperazine;1-Piperazineethylamine;2-(1-Piperazinyl)ethanamine;2-(1-Piperazinyl)ethylamine;2-Piperazinylethylamine;4-(2-Aminoethyl)piperazine;AEP;Ancamine AEP;N-(2-Aminoethyl)piperazine;N-(b-Aminoethyl)piperazine;N-AEP;NSC 38968; |
| EINECS: | 205-411-0 |
| Density: | 0.958 g/cm3 |
| Melting Point: | -19 °C |
| Boiling Point: | 220 °C at 760 mmHg |
| Flash Point: | 93.3 °C |
| Solubility: | soluble in water |
| Appearance: | colorless liquid |
| Hazard Symbols: |
C
|
| Risk Codes: | 21/22-34-43-52/53 |
| Safety: | 26-36/37/39-45-61 |
| Transport Information: | UN 2815 8/PG 3 |
| PSA: | 41.29000 |
| LogP: | -0.18270 |

2,5,8,10,13,16-Hexaazapentacyclo<8.6.1.12,5.09,18.013,17>octadecan


aminoethylpiperazine

| Conditions | Yield |
|---|---|
| With hydrogen; palladium on activated charcoal In ethanol at 125℃; under 41371.8 Torr; for 6h; | 94% |

2,2’-(ethane-1,2-diylbis(azanediyl))diacetonitrile

A

aminoethylpiperazine

B

triethylentetramine

| Conditions | Yield |
|---|---|
| With hydrogen at 120℃; under 150015 Torr; Concentration; Temperature; Pressure; | A 5.2% B 87.3% |
| With hydrogen In tetrahydrofuran; toluene at 120℃; under 150015 Torr; for 500h; Autoclave; | A 6.1% B 83.6% |
| With hydrogen In tetrahydrofuran; water; toluene at 120℃; under 90009 Torr; for 25h; Autoclave; | A 12.1% B 71.9% |
| With hydrogen; Cr-doped Raney cobalt catalyst In tetrahydrofuran; water at 120℃; under 150015 Torr; for 3h; Product distribution / selectivity; |

| Conditions | Yield |
|---|---|
| Stage #1: 2,2',2''-triaminotriethylamine With copper(II) perchlorate hexahydrate; acetonitrile Stage #2: With nitrogen(II) oxide In acetonitrile at 20℃; for 0.166667h; | A 60% B 30% |

A

aminoethylpiperazine

B

tetrakis(acetonitrile)copper(I) perchlorate

| Conditions | Yield |
|---|---|
| With NO In acetonitrile NO purged into soln. of Cu complex in degassed CH3CN (O2-free conditions); stirred (10 min, room temp.); NO removed; layered with benzene; cooled; | A 60% B n/a C 30% |


| Conditions | Yield |
|---|---|
| With sodium hydroxide | |
| With hydrogenchloride |

| Conditions | Yield |
|---|---|
| With ammonia at 100℃; |

| Conditions | Yield |
|---|---|
| With hydrogenchloride In water at 30 - 60℃; Rate constant; acid-catalyzed ring opening reactions at various temperature, Ea, ΔH are given; | |
| With hydrogenchloride In water at 30 - 60℃; Yield given; |


aminoethylpiperazine

| Conditions | Yield |
|---|---|
| With sodium hydroxide at 20℃; Rate constant; Thermodynamic data; Ea, ΔH(excit.), ΔS(excit.); |


aminoethylpiperazine

| Conditions | Yield |
|---|---|
| With sodium hydroxide at 20℃; Rate constant; Thermodynamic data; Ea, ΔH(excit.), ΔS(excit.); |

| Conditions | Yield |
|---|---|
| With water In acetonitrile at 30℃; Rate constant; |
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N-aminoethylpiperazine (140-31-8) could be used with Pharmaceutical Intermediates.
Also,Delamine N-Aminoethylpiperazine(140-31-8) is appropriate for use in:
Bitumen Chemicals
Corrosion Inhibitors
Epoxy Curing Agents
Lube Oil and fuel additives
Mineral Processing Aids
Polyamide Resins
Urethane chemicals
Wet Strength Resins
N-aminoethylpiperazine (140-31-8) is a reaction to produce ethylene dichloride and ammonia by-product of ethylenediamine class products.
N-aminoethylpiperazine (140-31-8) of the consumption of raw materials fixed: dichloroethane 2100kg / t, liquid ammonia 620kg / t, caustic soda (42%) 4143kg / t.
| 1. | skn-rbt 100 µg/24H open | AIHAAP American Industrial Hygiene Association Journal. 23 (1962),95. | ||
| 2. | skn-rbt 5 mg/24H SEV | 85JCAE Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,864. | ||
| 3. | eye-rbt 20 mg/24H MOD | 85JCAE Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,864. | ||
| 4. | sce-ham:ovr 125 µg/L | MUREAV Mutation Research. 320 (1994),31. | ||
| 5. | msc-ham:ovr 500 µg/L | MUREAV Mutation Research. 320 (1994),31. | ||
| 6. | otr-mus:lym 1 mL/L | ENMUDM Environmental Mutagenesis. 4 (1982),390. | ||
| 7. | orl-rat LD50:2140 mg/kg | AIHAAP American Industrial Hygiene Association Journal. 23 (1962),95. | ||
| 8. | ipr-mus LD50:250 mg/kg | NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD277-689 . | ||
| 9. | skn-rbt LD50:880 mg/kg | UCDS** Union Carbide Data Sheet. (Industrial Medicine and Toxicology Dept., Union Carbide Corp., 270 Park Ave., New York, NY 10017) 6/13/69 . |
