Following a single topical application of 10gm nadifloxacin 1% cream to normal human back skin, the highest plasma concentration was determined to be 107ng./ml with an elimination half-life of 19.4 hours. Approximately 0.09% of the administered dose was excreted in the urine over 48 hours post- dosing. The plasma concentration reached a steady state on Day 5 of repeated administration study when nadifloxacin 1% cream was applied at 5 gm twice daily to normal healthy individuals for a period of 7 days. The plasma concentration reached a peak of 4.1 ng/ml at 8 hours post-final dosing with an elimination half-Life of 23.2 hours. The urinary excretion rate reached 0.16% on Day 7.

The Nadifloxacin, with the CAS registry number 124858-35-1, is also known as 1H,5H-Benzo[ij]quinolizine-2-carboxylic acid, 9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-, (±)-. It belongs to the product categories of Intermediates & Fine Chemicals; Pharmaceuticals. This chemical's molecular formula is C₁₉H₂₁FN₂O₄ and molecular weight is 360.38. What's more, its systematic name is 9-Fluoro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid. This chemical is a topical fluoroquinolone antibiotic for the treatment of acne vulgaris. It is also used to treat bacterial skin infections.

Physical properties of Nadifloxacin are: (1)ACD/LogP: 2.491; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.25; (4)ACD/LogD (pH 7.4): 0.71; (5)ACD/BCF (pH 5.5): 26.17; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 306.78; (8)ACD/KOC (pH 7.4): 8.90; (9)#H bond acceptors: 6; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 81.08 Å²; (13)Index of Refraction: 1.669; (14)Molar Refractivity: 91.62 cm³; (15)Molar Volume: 245.686 cm³; (16)Polarizability: 36.321×10^-24cm³; (17)Surface Tension: 71.7 dyne/cm; (18)Density: 1.467 g/cm³; (19)Flash Point: 331.722 °C; (20)Enthalpy of Vaporization: 97.264 kJ/mol; (21)Boiling Point: 624.891 °C at 760 mmHg; (22)Vapour Pressure: 0 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(O)\C2=C\N4c1c(c(c(F)cc1C2=O)N3CCC(O)CC3)CCC4C
(2)Std. InChI: InChI=1S/C19H21FN2O4/c1-10-2-3-12-16-13(18(24)14(19(25)26)9-22(10)16)8-15(20)17(12)21-6-4-11(23)5-7-21/h8-11,23H,2-7H2,1H3,(H,25,26)
(3)Std. InChIKey: JYJTVFIEFKZWCJ-UHFFFAOYSA-N