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| Name |
Neoarsphenamine |
EINECS | 207-273-7 |
| CAS No. | 457-60-3 | Density | g/cm3 |
| PSA | 137.85000 | LogP | 0.94760 |
| Solubility | N/A | Melting Point |
N/A |
| Formula | C13H14 As2 N2 O4 S . Na | Boiling Point | °Cat760mmHg |
| Molecular Weight | 466.17 | Flash Point | °C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by intravenous and subcutaneous routes. When heated to decomposition it emits very toxic fumes of As, NOx, Na2O, and SOx. See also ARSENIC COMPOUNDS. | Risk Codes | 22 |
| Molecular Structure |
|
Hazard Symbols | Xn |
| Synonyms |
Methanol,[5-[(3-amino-4-hydroxyphenyl)arseno]-2-hydroxyanilino]-, 1-(hydrogensulfoxylate) (ester), monosodium salt (8CI); Sulfoxylic acid,mono[[[5-[(3-amino-4-hydroxyphenyl)diarsenyl]-2-hydroxyphenyl]amino]methyl]ester, monosodium salt (9CI); Neo-I.C.I.; Neoarsphenamine; Neosalvarsan;Novarsenobenzol; Novarsenobillon; Novarsenol; Sodium3,3'-diamino-4,4'-dihydroxyarsenobenzene-N-formaldehydesulfoxylate; Sodium3,3'-diamino-4,4'-dihydroxyarsenobenzene-N-methylene-sulfoxylate; Sodiump,p'-dihydroxy-m,m'-diaminoarsenobenzene-N-monomethanol sulfoxylate |
Neoarsphenamine Chemical Properties
IUPAC Name: Sodium [5-(3-amino-4-hydroxyphenyl)arsanylidenearsanyl-2-hydroxyanilino]methanesulfinate
Synonyms of Neosalvarsan (CAS NO.457-60-3): ((5-(3-Amino-4-hydroxyphenyl)arseno)-2-hydroxyanilino)methanol sulfoxylate sodium ; 3,3'-Diamino-4,4'-dihydroxyarsenobenzenemethylenesulfoxylate sodium ; Arsevan ; Arsphenamine methylenesulfoxylic acid sodium salt ; Neo-gargarol liquidum ; Sodium 3,3'-diamino-4,4'-dihydroxyarsenobenzene-N-formaldehydesulfoxylate ; Sulfoxylic acid, mono(((5-((3-amino-4-hydroxyphenyl)diarsenyl)-2-hydroxyphenyl)amino)methyl) ester, monosodium salt
CAS NO: 457-60-3
Molecular Formula: C13H13As2N2NaO4S
Molecular Weight : 466.15
Molecular Structure: .png)
EINECS: 207-273-7
Appearance: Yellow powder or granules.
Water solubility: Soluble in water, insoluble in alcohol, chloroform and ether.
Neoarsphenamine History
Neosalvarsan is a synthetic chemotherapeutic that is an organoarsenic compound. They were replaced for this indication by penicillin in the 1940s, because both of these arsenicals carried considerable risk of side-effects. It became available in 1912 and superseded the more toxic and less water-soluble salvarsan as an effective treatment for syphilis.
Neoarsphenamine Uses
Neosalvarsan (CAS NO.457-60-3) is used as an effective treatment for syphilis.
Neoarsphenamine Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LDLo | intraperitoneal | 75mg/kg (75mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917. | |
| guinea pig | LDLo | subcutaneous | 75mg/kg (75mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917. | |
| mouse | LD50 | intravenous | 370mg/kg (370mg/kg) | Therapie. Vol. 2, Pg. 28, 1947. | |
| mouse | LDLo | intraperitoneal | 75mg/kg (75mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917. | |
| mouse | LDLo | subcutaneous | 100mg/kg (100mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917. | |
| rabbit | LDLo | intravenous | 150mg/kg (150mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917. | |
| rat | LD50 | intravenous | 318mg/kg (318mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Journal of Pharmacology and Experimental Therapeutics. Vol. 73, Pg. 12, 1941. |
| rat | LDLo | intraperitoneal | 50mg/kg (50mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917. | |
| rat | LDLo | subcutaneous | 75mg/kg (75mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917. |
Neoarsphenamine Consensus Reports
Arsenic and its compounds are on the Community Right-To-Know List.
Neoarsphenamine Safety Profile
Hazard Codes: 
Xn
Risk Statements: 22
R22: Neosalvarsan (CAS NO.457-60-3) is harmful if swallowed.
Safety Statements: 24/25-36
S24/25: Avoid contact with skin and eyes.
S36: Wear suitable protective clothing.
Poison by intravenous and subcutaneous routes. When heated to decomposition it emits very toxic fumes of As, NOx, Na2O, and SOx. See also ARSENIC COMPOUNDS.
Neoarsphenamine Standards and Recommendations
OSHA PEL: TWA 0.5 mg(As)m3
ACGIH TLV: BEI: 35 µ (As)/L inorganic arsenic and methylated metabolites in urine
Neoarsphenamine Specification
Neosalvarsan (CAS NO.457-60-3) is easily oxidized in the air,and accelerate oxidation when the temperature is high .
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