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| CAS No.: | 63770-20-7 |
|---|---|
| Name: | CONGOCIDINE |
| Molecular Structure: | |
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|
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| Formula: | C18H26 N10 O3 . x Cl H |
| Molecular Weight: | 467.00 |
| Synonyms: | 1H-Pyrrole-2-carboxamide,4-[[[(aminoiminomethyl)amino]acetyl]amino]-N-[5-[[(3-amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-1-methyl-,hydrochloride (9CI); Netropsin hydrochloride (7CI) |
| Boiling Point: | 724.2°C at 760 mmHg |
| Flash Point: | 391.8°C |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | R22 |
| Safety: | Poison by subcutaneous and intravenous routes. Mutation data reported. An antibacterial agent. When heated to decomposition it emits very toxic fumes of HCl and NOx. |
| PSA: | 208.93000 |
| LogP: | 3.22520 |
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Chemistry
Chemistry informtion about Netropsin Hydrochloride (CAS NO.63770-20-7) is:
IUPAC Name: 4-[[4-[[1-Amino-2-(Diaminomethylideneamino)Ethylidene]Amino]-1-Methylpyrrole-2-Carbonyl]Amino]-N-(3-Amino-3-Oxopropyl)-1-Methylpyrrole-2-Carboxamide Hydrochloride
Synonyms: Congocidin Dihydrochloride ; Congocidine ; Netropsin 2HCl ; Netropsin Dihydrochloride ; Netropsin, Dihydrochloride, Streptomyces Netropsis ; Sinanomycin ; Sinanomycin Dihydrochloride
MF: C18H28Cl2N10O3
MW: 503.39
Flash Point: 391.8 °C
Boiling Point: 724.2 °C at 760 mmHg
Vapour Pressure: 3E-21 mmHg at 25°C
Enthalpy of Vaporization: 107.64 kJ/mol
Storage temp.: −20°C
Following is the molecular structure of Netropsin Hydrochloride (CAS NO.63770-20-7) is:
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Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intravenous | 17mg/kg (17mg/kg) | Journal of the American Chemical Society. Vol. 73, Pg. 341, 1951. | |
| mouse | LD50 | oral | > 300mg/kg (300mg/kg) | Journal of the American Chemical Society. Vol. 73, Pg. 341, 1951. | |
| mouse | LD50 | subcutaneous | 70mg/kg (70mg/kg) | Journal of the American Chemical Society. Vol. 73, Pg. 341, 1951. |
Safety Profile
Poison by subcutaneous and intravenous routes. Mutation data reported. An antibacterial agent. When heated to decomposition it emits very toxic fumes of HCl and NOx.
Hazard Codes:
Xn
Risk Statements:
R22:Harmful if swallowed.
Safety Statements:
S36:Wear suitable protective clothing.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: DW2973000
Specification
Netropsin Hydrochloride (CAS NO.63770-20-7) is a faint yellow powder. Unusual n-methylpyrrole-containing oligopeptide that binds to AT-rich sequences of dsDNA, especially in the minor groove. Thus, it protects such regions from DNase I and other endonucleases, and also inhibits topoisomerases. Netropsin Hydrochloride disrupts the cell cycle, prolonging G and arresting in G.