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Nialamide

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Name

Nialamide

EINECS N/A
CAS No. 51-12-7 Density 1.203g/cm3
PSA 83.12000 LogP 2.19520
Solubility N/A Melting Point 152-154 °C(lit.)

Formula C16H18 N4 O2 Boiling Point 538.1°Cat760mmHg
Molecular Weight 298.345 Flash Point 279.2°C
Transport Information N/A Appearance N/A
Safety Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Mutation data reported. Experimental reproductive effects. An antidepressant. When heated to decomposition it emits toxic fumes of NOx. Risk Codes R20/21/22; R36/37/38; R40
Molecular Structure Molecular Structure of 51-12-7 (NIALAMIDE) Hazard Symbols Toxic in overdose.
Synonyms

Isonicotinicacid, 2-[2-(benzylcarbamoyl)ethyl]hydrazide (6CI,7CI,8CI); 1-[2-(Benzylcarbamoyl)ethyl]-2-isonicotinoylhydrazine;Espril; N1-Beta-Benzylcarbamoyl-ethyl-N2-isonicotinoyl-hydrazine; NSC 124514;Nialamid; Nialamide; Niamid; Niamidal; Niamide; Niaquitil; Niazin; Novazid;Nuredal; Nyezin

 

Nialamide Chemical Properties

Product Name: Nialamide   
CAS: 51-12-7
The Molecular formula of Nialamide (CAS NO.51-12-7): C16H18N4O2
The Molecular Weight of Nialamide (CAS NO.51-12-7): 298.34
The Molecular Structure of Nialamide (CAS NO.51-12-7):

Density: 1.203 g/cm3 
Flash Point: 279.2 °C
Boiling Point: 538.1 °C at 760 mmHg
Melting Point: 152-154 °C(lit.)  
Index of Refraction: 1.589 
Molar Refractivity: 83.57 cm3 
Molar Volume: 247.9 cm3 
Polarizability: 33.13×10-24cm3 
Surface Tension: 52.3 dyne/cm 
Enthalpy of Vaporization: 81.52 kJ/mol 
Vapour Pressure: 1.19E-11 mmHg at 25°

Nialamide Toxicity Data With Reference

1.    

mma-sat 10 µg/plate

    PLRCAT    Pharmacological Research Communications. 12 (1980),423.
2.    

mmo-sat 10 µg/plate

    MUREAV    Mutation Research. 40 (1976),305.
3.    

dnr-esc 27 µmol/plate

    JTEHD6    Journal of Toxicology and Environmental Health. 9 (1982),287.
4.    

oms-bcs 10 mmol/L

    MUREAV    Mutation Research. 5 (1968),343.
5.    

dnd-mus-ipr 2450 µmol/kg

    CNREA8    Cancer Research. 41 (1981),1469.
6.    

sce-mus-ipr 435 mg/kg

    JTEHD6    Journal of Toxicology and Environmental Health. 9 (1982),287.
7.    

orl-rat LD50:1700 mg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 1 (1959),524.
8.    

ipr-rat LD50:760 mg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 1 (1959),524.
9.    

orl-mus LD50:590 mg/kg

    27ZQAG    Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,269.
10.    

ipr-mus LD50:200 mg/kg

    MPHEAE    Medicina et Pharmacologia Experimentalis. 16 (1967),267.
11.  

Nialamide Consensus Reports

EPA Genetic Toxicology Program.

Nialamide Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Mutation data reported. Experimental reproductive effects. An antidepressant. When heated to decomposition it emits toxic fumes of NOx.
Safety Information about Nialamide (CAS NO.51-12-7):
Hazard Codes: 
Xn:
Risk Statements about Nialamide (CAS NO.51-12-7):
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
R40: Limited evidence of a carcinogenic effect.
Safety Statements about Nialamide (CAS NO.51-12-7):
S22: Do not breathe dust.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
F10: Keep under argon.
RIDADR: 3249
WGK Germany: 3
RTECS: NS1225000
HazardClass: 6.1(b)
PackingGroup: III

Nialamide Specification

  Nialamide with CAS number of 51-12-7 is also named as 1-(2-(Benzylcarbamoyl)ethyl)-2-isonicotinoylhydrazine ; 2-(2-(Benzylcarbamoyl)ethyl)hydrazide isonicotinic acid ; 2-(2-(Benzylcarbamyl)ethyl)hydrazide isonicotinic acid ; 4-Pyridinecarboxylic acid 2-(3-oxo-3- ; ((phenylmethyl)amino)propyl)hydrazide ; 5-22-02-00251 (Beilstein Handbook Reference) ; BEIH ; BRN 0492941 ; CCRIS 3512 ; Delmoneurina ; Delmoneurinaesprilisalizina ; EINECS 200-079-3 ; Espril ; Isalizina ; Isonicotinic acid 2-((2-benzylcarbamoyl)ethyl)hydrazide ; Isonicotinic acid, 2-(2-(benzylcarbamoyl)ethyl)hydrazide ; Mygal ; N(sup 1)-beta-Benzylcarbamoylethyl-N(sup 2)-isonicotinoylhydrazine ; N(sup1)-beta-Benzylcarbamoylethyl-N(sup2)-isonicotinoylhydrazine ; N-(2-(Benzylcarbamyl)ethylamino)isonicotinamide ; N-Benzyl-beta-(isonicotinoylhydrazine)propionamide ; N-Benzyl-beta-(isonicotinylhydrazino)propionamide ; N-Isonicotinoyl-N'(beta-N-benzylcarboxamidoethyl)hydrazine ; NSC 124514 ; Nialamid ; Nialamida ; Nialamida [INN-Spanish] ; Nialamide ; Nialamidum ; Nialamidum [INN-Latin] ; Niamid ; Niamidal ; Niamide ; Niaquitil ; Niazin ; Novazid ; Nuredal ; Nyazin ; P 1133 ; Psicodisten ; Surgex ; UNII-T2Q0RYM725 . Nialamide is sometimes used in the treatment of trigeminal neuralgia. It has also been studied for alcoholism, dermatomally distributed vitiligo, irregular menstruation, angina, cerebrovascular disorders, and the prevention of streptomycin-induced deafness.Side effects of nialamide include euphoria, psychomotor agitation, insomnia, anxiety, headache, vertigo, tremor, hyperreflexia, manic state, arterial hypotension, orthostatic hypotension, arterial hypertension, palpitations, hyperhidrosis, dry mouth, nausea, vomiting, epigastric pain, constipation, vision problems, retrobulbar optic neuritis, polyneuritis, weight gain, acute cardiac insufficiency, tachycardia, peripheral neuropathy, jaundice, hepatomegaly, hyperbilirubinemia, urinary retention, elevated transaminases, hepatitis, hepatocellular insufficiency, cutaneous eruption, impotence, and delayed ejaculation.

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