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Nicaraven

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Name

Nicaraven

EINECS 1806241-263-5
CAS No. 79455-30-4 Density 1.213 g/cm3
PSA 83.98000 LogP 1.80670
Solubility N/A Melting Point 156-157°
Formula C15H16N4O2 Boiling Point 635.9 °C at 760 mmHg
Molecular Weight 284.318 Flash Point 338.4 °C
Transport Information N/A Appearance N/A
Safety Risk Codes N/A
Molecular Structure Molecular Structure of 79455-30-4 (Nicaraven) Hazard Symbols N/A
Synonyms

1,2-Bis(nicotinamido)propane;AVS;Antevas;Nicaraven;

Article Data 4

Nicaraven Specification

The Nicaraven is an organic compound with the formula C15H16N4O2. The IUPAC name of this chemical is N-[2-(pyridine-3-carbonylamino)propyl]pyridine-3-carboxamide. With the CAS registry number 79455-30-4, it is also named as 3-Pyridinecarboxamide, N,N'-(1-methyl-1,2-ethanediyl)bis-. The product's classification codes are Antioxidants; Drug / Therapeutic Agent; Protective Agents; Reproductive Effect.

Physical properties about Nicaraven are: (1)ACD/LogP: 0.44; (2)ACD/LogD (pH 5.5): 0.43; (3)ACD/LogD (pH 7.4): 0.44; (4)ACD/BCF (pH 5.5): 1.25; (5)ACD/BCF (pH 7.4): 1.27; (6)ACD/KOC (pH 5.5): 40.68; (7)ACD/KOC (pH 7.4): 41.27; (8)#H bond acceptors: 6; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 5; (11)Polar Surface Area: 66.4 Å2; (12)Index of Refraction: 1.584; (13)Molar Refractivity: 78.47 cm3; (14)Molar Volume: 234.3 cm3; (15)Polarizability: 31.11×10-24cm3; (16)Surface Tension: 53.6 dyne/cm; (17)Density: 1.213 g/cm3; (18)Flash Point: 338.4 °C; (19)Enthalpy of Vaporization: 93.96 kJ/mol; (20)Boiling Point: 635.9 °C at 760 mmHg; (21)Vapour Pressure: 4.53E-16 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(NC(C)CNC(=O)c1cccnc1)c2cccnc2
(2)InChI: InChI=1/C15H16N4O2/c1-11(19-15(21)13-5-3-7-17-10-13)8-18-14(20)12-4-2-6-16-9-12/h2-7,9-11H,8H2,1H3,(H,18,20)(H,19,21)
(3)InChIKey: KTXBOOWDLPUROC-UHFFFAOYAG
(4)Std. InChI: InChI=1S/C15H16N4O2/c1-11(19-15(21)13-5-3-7-17-10-13)8-18-14(20)12-4-2-6-16-9-12/h2-7,9-11H,8H2,1H3,(H,18,20)(H,19,21)
(5)Std. InChIKey: KTXBOOWDLPUROC-UHFFFAOYSA-N

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 1500mg/kg (1500mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 23(Suppl,
mouse LD unreported > 1gm/kg (1000mg/kg)   European Patent Application. Vol. #0029602,
mouse LD50 intravenous 590mg/kg (590mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 23(Suppl,
rat LD50 intravenous 840mg/kg (840mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 23(Suppl,

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