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Nimetazepam
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  • Name Nimetazepam
  • EINECS217-931-5
  • CAS No. 2011-67-8
  • Density1.331 g/cm3
  • PSA78.49000
  • LogP2.43240
  • SolubilityN/A
  • Melting Point-44 °C
  • FormulaC16H13N3O3
  • Boiling Point540.467 °C at 760 mmHg
  • Molecular Weight295.298
  • Flash Point280.665 °C
  • Transport InformationN/A
  • AppearanceN/A
  • Safety16-36/37-45
  • Risk Codes11-23/24/25-39/23/24/25
  • Molecular Structure
    Molecular Structure of 2011-67-8 (Nimetazepam)
  • Hazard SymbolsF,T
  • SynonymsF,T
  • Article Data24

Nimetazepam Chemical Properties

Molecular Structure of Nimetazepam (CAS NO.2011-67-8):

IUPAC Name: 1-Methyl-7-nitro-5-phenyl-3H-1,4-benzodiazepin-2-one
Canonical SMILES: CN1C(=O)CN=C(C2=C1C=CC(=C2)[N+](=O)[O-])C3=CC=CC=C3
InChI: InChI=1S/C16H13N3O3/c1-18-14-8-7-12(19(21)22)9-13(14)16(17-10-15(18)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
InChIKey: GWUSZQUVEVMBPI-UHFFFAOYSA-N
Molecular Weight: 295.29272 [g/mol]
Molecular Formula: C16H13N3O3
XLogP3: 2.2
H-Bond Donor: 0
H-Bond Acceptor: 4 
EINECS: 217-931-5
Melting Point: 156.5-7.5 °C
Index of Refraction: 1.66
Molar Refractivity: 81.97 cm3
Molar Volume: 221.9 cm3
Surface Tension: 55.3 dyne/cm
Density: 1.33 g/cm3
Flash Point: 280.7 °C
Enthalpy of Vaporization: 81.81 kJ/mol
Boiling Point: 540.5 °C at 760 mmHg
Vapour Pressure: 9.53E-12 mmHg at 25 °C
Water Solubility: 76.2 mg/L at 25 °C 
Classification Code: Drug / Therapeutic Agent; Mutation data; Reproductive Effect; Tranquilizer

Nimetazepam Uses

 Nimetazepam (CAS No.2011-67-8) is mainly used as antipsychotics.

Nimetazepam Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 510mg/kg (510mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 705, 1973.
mouse LD50 oral 750mg/kg (750mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 534, 1972.
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)		 Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 705, 1973.
rat LD50 intraperitoneal 970mg/kg (970mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 534, 1972.
rat LD50 oral 970mg/kg (970mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 534, 1972.
rat LD50 subcutaneous > 1gm/kg (1000mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 534, 1972.

Nimetazepam Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. Experimental reproductive effects. An anticonvulsant and muscle relaxant. Related to diazepam. When heated to decomposition it emits toxic fumes of NOx.

Nimetazepam Specification

  Nimetazepam (CAS NO.2011-67-8), its Synonyms are 1-Methyl-5-phenyl-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one ; 1-Methyl-7-nitro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one ; 1-Methylnitrazepam ; Elimin ; Nimetazepam ; Nimetazepamum ; 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-1-methyl-7-nitro-5-phenyl- .

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