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Nocodazole

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Name

Nocodazole

EINECS 250-626-5
CAS No. 31430-18-9 Density 1.491 g/cm3
PSA 112.32000 LogP 3.10670
Solubility DMSO: 10 mg/mL, soluble Melting Point 300 °C (dec.)
Formula C14H11N3O3S Boiling Point N/A
Molecular Weight 301.326 Flash Point N/A
Transport Information UN 2811 Appearance Amber powder
Safety 53-45-36/37/39-26 Risk Codes 61-40-36/37/38-34-11
Molecular Structure Molecular Structure of 31430-18-9 (NOCODAZOLE) Hazard Symbols ToxicT, CorrosiveC, FlammableF
Synonyms

2-Benzimidazolecarbamicacid, 5-(2-thenoyl)-, methyl ester (8CI);Carbamic acid,[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-, methyl ester (9CI);Methyl[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate;N-[5-(2-Thenoyl)-2-benzimidazolyl]carbamic acid methyl ester;NSC 238159;Oncodazole;R 17934;

Article Data 3

Nocodazole Chemical Properties

MF: C14H11N3O3S
MW: 301.32
EINECS: 250-626-5
mp:  300 °C (dec.)
storage temp:  2-8°C
solubility  DMSO: 10 mg/mL, soluble
form:  powder
color:  white
Synonyms:[5-(2-THIENYLCARBONYL)-1H-BENZIMIDAZOL-2-YL]CARBONIC ACID, METHYL ESTER;METHYL[5-(2-THIENYLCARBONYL)-1H-BENZIMADAZOL-2-YL]CARBAMATE;METHYL-(5-[2-THIENYLCARBONYL]-1H-BENZIMIDAZOL-2-YL)CARBAMATE;METHYL [5-(2-THIENYLCARBONYL)-1H-BENZ-IMIDAZOLE-2-YL]-CARBAMATE;METHYL-(5-[2-THIENYLCARBONYL]-1H-BENZIMODAZOL-2YL)-CARBAMATE;METHYL N-(5-THENOYL-2-BENZIMIDAZOLYL)CARBAMATE;NOCODAZOLE;R 17934
Molecular Structure:

Nocodazole Uses

ONCODAZOLE is used as a synthetic chemotherapeutic agent with antineoplastic, antifungal and anthelmintic activities. Microtubule inhibitor; inhibits mitosis.

Nocodazole Toxicity Data With Reference

1.   

sln-smc 1 ppm/16H

   MUREAV    Mutation Research. 141 (1984),15.
2.   

cyt-hmn:hla 40 µg/L

   CNREA8    Cancer Research. 36 (1976),905.
3.   

ipr-mus LD50:39,350 µg/kg

   NCISP*    National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program, Bethesda, MD 20205 JAN86 .

Nocodazole Safety Profile

Poison by intraperitoneal route. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of SOx and NOx. See also CARBAMATES.
Hazard Codes  T,C,F
Risk Statements  61-40-36/37/38-34-11
Safety Statements  53-45-36/37/39-26-16
RIDADR  2811
WGK Germany  3
RTECS  DD6521000
HazardClass  6.1(b)
PackingGroup  III

Nocodazole Specification

Handling and Storage of ONCODAZOLE: 
Handling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood. 
Storage: Store in a tightly closed container. Store in a dry area. Deep freeze (below -20°C). 

 

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