Basic Information | Post buying leads | Suppliers | Cas Database |
The Osalmid with CAS registry number of 526-18-1 is also known as 4'-Hydroxysalicylanilide. The IUPAC name is 2-Hydroxy-N-(4-hydroxyphenyl)benzamide. Its EINECS registry number is 208-385-9. In addition, the formula is C13H11NO3 and the molecular weight is 229.23. This chemical is prepared by reaction of phenyl salicylate with aminophenol.
Physical properties about Osalmid are: (1)ACD/LogP: 2.53; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.52; (4)ACD/LogD (pH 7.4): 2.46; (5)ACD/BCF (pH 5.5): 48.82; (6)ACD/BCF (pH 7.4): 42; (7)ACD/KOC (pH 5.5): 562.43; (8)ACD/KOC (pH 7.4): 483.87; (9)#H bond acceptors: 4; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 4; (12)Index of Refraction: 1.71; (13)Molar Refractivity: 64.59 cm3; (14)Molar Volume: 165.1 cm3; (15)Surface Tension: 69.5 dyne/cm; (16)Density: 1.387 g/cm3; (17)Flash Point: 165.9 °C; (18)Enthalpy of Vaporization: 61.89 kJ/mol; (19)Boiling Point: 350.8 °C at 760 mmHg; (20)Vapour Pressure: 2.12E-05 mmHg at 25 °C.
Uses of Osalmid: it is used to produce 2-methyl-3-(4-vinyloxy-phenyl)-2,3-dihydro-benzo[e][1,3]oxazin-4-one by reaction with ethyne. The reaction occurs with catalysts KOH, CdO and solvent dioxane at 200 °C for 1.5 hours. The yield is about 54%. Besides, the reaction pressure is 8360.004-9120.004. What's more, it is used for cholecystitis, bile duct inflammation, cholelithiasis and bile duct syndrome after surgery.
When you are using this chemical, please be cautious about it. As a chemical, it is irritating to eyes, respiratory system and skin. It is harmful if swallowed and may cause sensitisation by inhalation and skin contact. During using it, wear suitable protective clothing and gloves. If contact with eyes accidently, rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
1. Canonical SMILES: C1=CC=C(C(=C1)C(=O)NC2=CC=C(C=C2)O)O
2. InChI: InChI=1S/C13H11NO3/c15-10-7-5-9(6-8-10)14-13(17)11-3-1-2-4-12(11)16/h1-8,15-16H,(H,14,17)
3. InChIKey: LGCMKPRGGJRYGM-UHFFFAOYSA-N
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 517mg/kg (517mg/kg) | Drugs in Japan Vol. 6, Pg. 159, 1982. | |
mouse | LD50 | intravenous | 180mg/kg (180mg/kg) | U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03234, | |
mouse | LD50 | oral | 1050mg/kg (1050mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Japanese Journal of Pharmacology. Vol. 22, Pg. 235, 1972. |
mouse | LD50 | subcutaneous | 1900mg/kg (1900mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 116, Pg. 154, 1958. | |
rat | LD50 | intraperitoneal | 1484mg/kg (1484mg/kg) | Drugs in Japan Vol. -, Pg. 290, 1995. | |
rat | LD50 | oral | 6702mg/kg (6702mg/kg) | Drugs in Japan Vol. 6, Pg. 159, 1982. | |
rat | LD50 | subcutaneous | > 5gm/kg (5000mg/kg) | Drugs in Japan Vol. 6, Pg. 159, 1982. |