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Cas Database |
| Name |
Oxaprozin |
EINECS | 244-296-1 |
| CAS No. | 21256-18-8 | Density | 1.222 g/cm3 |
| PSA | 63.33000 | LogP | 4.02580 |
| Solubility | 4mg/L(37 oC) | Melting Point |
154 °C |
| Formula | C18H15NO3 | Boiling Point | 467 °C at 760 mmHg |
| Molecular Weight | 293.322 | Flash Point | 236.2 °C |
| Transport Information | N/A | Appearance | solid |
| Safety | 24/25-36/37/39-36-26 | Risk Codes | 20/21/22-36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 Xn, Xi
|
| Synonyms |
2-Oxazolepropionicacid, 4,5-diphenyl- (8CI);3-(4,5-Diphenyloxazol-2-yl)propionic acid;4,5-Diphenyl-2-oxazolepropionic acid;Actirin;Alvo;Daypro;Durapro;Duraprost;NSC 310839;Oxapro;2-Oxazolepropanoicacid, 4,5-diphenyl-;Wy 21743;b-(4,5-Diphenyloxazol-2-yl)propionic acid; |
Article Data | 15 |
Oxaprozin Chemical Properties
Molecule structure of Oxaprozin (CAS NO.21256-18-8):
IUPAC Name: 3-(4,5-Diphenyl-1,3-oxazol-2-yl)propanoic acid
Molecular Weight: 293.3166 g/mol
Molecular Formula: C18H15NO3
Density: 1.222 g/cm3
Melting Point: 154 °C
Boiling Point: 467 °C at 760 mmHg
Flash Point: 236.2 °C
Index of Refraction: 1.595
Molar Refractivity: 81.57 cm3
Molar Volume: 239.9 cm3
Surface Tension: 50.6 dyne/cm
Enthalpy of Vaporization: 76.8 kJ/mol
Vapour Pressure: 1.6E-09 mmHg at 25 °C
XLogP3: 4.2
H-Bond Donor: 1
H-Bond Acceptor: 4
Rotatable Bond Count: 5
Tautomer Count: 2
Exact Mass: 293.105193
MonoIsotopic Mass: 293.105193
Topological Polar Surface Area: 63.3
Heavy Atom Count: 22
Canonical SMILES: C1=CC=C(C=C1)C2=C(OC(=N2)CCC(=O)O)C3=CC=CC=C3
InChI: InChI=1S/C18H15NO3/c20-16(21)12-11-15-19-17(13-7-3-1-4-8-13)18(22-15)14-9-5-2-6-10-14/h1-10H,11-12H2,(H,20,21)
InChIKey: OFPXSFXSNFPTHF-UHFFFAOYSA-N
EINECS: 244-296-1
Product Categories: Carboxylic Acids; Oxazoles, Isoxazoles & Benzoxazoles; APIs; Carboxylic Acids; Oxazoles, Isoxazoles & Benzoxazoles
Oxaprozin Uses
Oxaprozin (CAS NO.21256-18-8) is a non-steroidal anti-inflammatory drug (NSAID), used to relieve theswelling, stiffness, inflammation and joint pain associated with osteoarthritis and rheumatoid arthritis.
Oxaprozin Toxicity Data With Reference
| 1. | orl-rbt TDLo:39 mg/kg (female 6-18D post):TER | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 15 (1984),250. | ||
| 2. | orl-rat LD50:4470 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 15 (1984),359. | ||
| 3. | ipr-rat LD50:506 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 15 (1984),359. | ||
| 4. | scu-rat LD50:2910 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 15 (1984),359. | ||
| 5. | ivn-rat LD50:82 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 15 (1984),359. | ||
| 6. | orl-mus LD50:1210 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 15 (1984),359. | ||
| 7. | ipr-mus LD50:376 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 15 (1984),359. | ||
| 8. | scu-mus LD50:556 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 15 (1984),359. | ||
| 9. | ivn-mus LD50:93 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 15 (1984),359. | ||
| 10. | ipr-dog LD50:200 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 15 (1984),359. |
Oxaprozin Safety Profile
Hazard Codes: 
Xn, 
Xi
Risk Statements: 20/21/22-36/37/38
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 24/25-36/37/39-36-26
S24/25:Avoid contact with skin and eyes.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S36:Wear suitable protective clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
RTECS: RP6990000
Hazard Note: Irritant
Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by subcutaneous route. An experimental teratogen. Experimental reproductive effects. An anti-inflammatory agent. When heated to decomposition it emits toxic fumes of NOx.
Oxaprozin Specification
Oxaprozin (CAS NO.21256-18-8) is also named as 3-(4,5-Diphenyl-2-oxazolyl)propenoic acid ; 4,5-Diphenyl-2-oxazolepropanoic acid ; Alvo ; BRN 1083168 ; Daypro ; Deflam ; HSDB 7586 ; NSC 310839 ; Oxaprozina ; Oxaprozina [INN-Spanish] ; Oxaprozine ; Oxaprozine [INN-French] ; Oxaprozinum ; Oxaprozinum [INN-Latin] ; UNII-MHJ80W9LRB ; Voir ; WY-21743 ; beta-(4,5-Diphenyloxazol-2-yl)propionic acid .
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