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Oxazepam
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Name

Oxazepam

 EINECS 210-076-9
CAS No. 604-75-1 Density 1.42g/cm3
PSA N/A LogP N/A
Solubility 20mg/L(22 oC) Melting Point 205-206oC
Formula C15H11 Cl N2 O2 Boiling Point 506.5oC at 760 mmHg
Molecular Weight 286.718 Flash Point 11°C
Transport Information N/A Appearance N/A
Safety Moderately toxic by intraperitoneal route. Human (child) systemic effects by ingestion: somnolence, changes in REM sleep, and loss of muscle control (ataxia). Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Used to treat anxiety and tension. When heated to decomposition it emits very toxic fumes of NOx and HCl. See also DIAZEPAM. Risk Codes 40-39/23/24/25-23/24/25-11
Molecular Structure Molecular Structure of 604-75-1 (OXAZEPAM) Hazard Symbols Xn,T,F
Synonyms

(RS)-Oxazepam;(?à)-Oxazepam; 3-Hydroxynordiazepam;7-Chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one;7-Chloro-3-hydroxy-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; Adumbran;Anxiolit; Anxiolit retard; Aplakil; Astress; Azutranquil; Bonare; Drimuel;Droxacepam; Durazepam; Enidrel; Hi-Long; Isodin; Lederpam; Limbial; N-Desmethyltemazepam;NSC 169448; Nesontil; Noctazepam; Nortemazepam; Nozepam; Oxa-puren; Oxanid;Oxazepam; Praxiten; Propax; Psiquiwas; Quilibrex; Ro 5-6789; Rondar; Serax;Serenal; Serenid; Serepax; Seresta; Sigacalm; Sobril; Tarchomin; Tazepam;Uskan; Wy 3498; Zaxopam

Article Data 37

Oxazepam Chemical Properties

IUPAC Name: 7-Chloro-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
Synonyms: (±)-Oxazepam ; 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl- ; 7-Chlor-3-hydroxy-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-on ; 7-Chloro-3-hydroxy-5-phényl-1,3-dihydro-2H-1,4-benzodiazépin-2-one
Molecular Structure of 7-Chloro-1,3-dihydro-3-hydroxy-5-phenyl-2h-1,4-benzodiazepine-2-one (CAS NO.604-75-1) :
Molecular Formula of 7-Chloro-1,3-dihydro-3-hydroxy-5-phenyl-2h-1,4-benzodiazepine-2-one (CAS NO.604-75-1) : C15H11ClN2O2
Molecular Weight of 7-Chloro-1,3-dihydro-3-hydroxy-5-phenyl-2h-1,4-benzodiazepine-2-one (CAS NO.604-75-1) : 286.71
CAS NO: 604-75-1
EINECS: 210-076-9
Index of Refraction: 1.681
Surface Tension: 54.6 dyne/cm
Density: 1.42 g/cm3
Flash Point: 260.2 °C
Enthalpy of Vaporization: 81.76 kJ/mol
Boiling Point: 506.5 °C at 760 mmHg
Vapour Pressure: 4.4E-11 mmHg at 25°C
Storage temp: -20°C

Oxazepam Uses

 7-Chloro-1,3-dihydro-3-hydroxy-5-phenyl-2h-1,4-benzodiazepine-2-one (CAS NO.604-75-1) has effects on sedation, hypnosis, anti-anxiety, anticonvulsant and muscle relaxant.

Oxazepam Toxicity Data With Reference

1.    

mma-sat 5200 pmol/plate

     CNREA8    Cancer Research. 38 (1978),4478.
2.    

orl-mus TDLo:2520 mg/kg (1-21D preg/21D post):REP

     PLRCAT    Pharmacological Research Communications. 9 (1977),325.
3.    

orl-mus TDLo:120 g/kg/57 W-C:ETA

     TOXID9    Toxicologist. 13 (1993),373.
4.    

orl-chd TDLo:8 mg/kg:CNS

     JAMAAP    JAMA, Journal of the American Medical Association. 196 (1966),662.
5.    

ipr-rat LD50:1535 mg/kg

     PHMGBN    Pharmacology: International Journal of Experimental and Clinical Pharmacology. 10 (1973),345.
6.    

ipr-mus LD50:767 mg/kg

     JMCMAR    Journal of Medicinal Chemistry. 11 (1968),777.

Oxazepam Consensus Reports

IARC Cancer Review: Group 3 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 13 , 1977,p. 57.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210)

Oxazepam Safety Profile

Moderately toxic by intraperitoneal route. Human (child) systemic effects by ingestion: somnolence, changes in REM sleep, and loss of muscle control (ataxia). Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Used to treat anxiety and tension. When heated to decomposition it emits very toxic fumes of NOx and HCl. See also DIAZEPAM.
Hazard CodesHarmfulXn,ToxicT,FlammableF
Risk Statements 40-39-23/24/25-11
R11:Highly flammable. 
R39:Danger of very serious irreversible effects. 
R40:Limited evidence of a carcinogenic effect. 
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
Safety Statements 7-16-36/37-45
S7:Keep container tightly closed. 
S16:Keep away from sources of ignition. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S36/37:Wear suitable protective clothing and gloves.
RIDADR UN 1230 3/PG 2
WGK Germany 3
RTECS DF1400000
HazardClass 6.1(b)
PackingGroup III

Oxazepam Specification

1.General Description: Odorless creamy-white to pale-yellow powder or white crystalline solid. Bitter taste. pH (2% aqueous suspension) 4.8-7.
2.Air & Water Reactions: Insoluble in water.
3.Reactivity Profile: Oxazepam is stable in light and is non hygroscopic. Oxazepam is stable in neutral solution.Oxazepam is hydrolyzed by acids and bases.
4.Fire Hazard :Flash point data for Oxazepam are not available; however, Oxazepam is probably combustible.