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Name |
PICROTOXIN |
EINECS | N/A |
CAS No. | 124-87-8 | Density | g/cm3 |
PSA | 190.95000 | LogP | -0.92920 |
Solubility | 4.083g/L(room temperature) | Melting Point |
203 °C(lit.) |
Formula | C15H18O7•C15H16O6 | Boiling Point | 595.8°Cat760mmHg |
Molecular Weight | 602.592 | Flash Point | 228.9°C |
Transport Information | N/A | Appearance | N/A |
Safety | A human poison by ingestion. Poison experimentally by most routes. Human systemic effects by ingestion: somnolence, gastrointestinal effects. An alkaloid convulsant poison. When heated to decomposition it emits acrid smoke and irritating fumes. | Risk Codes | 28-52/53 |
Molecular Structure | Hazard Symbols | Toxic in overdose. | |
Synonyms |
)-3,6-methano-8h-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3h)-dione(;1:1)[qr];3,6-methano-8h-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3h)-dione,hex;3beta,6beta,6abeta,8as*,8bbeta,9s*))-,compdwith(1ar-(1aalpha,2abeta,3beta,6b;ahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-,(1ar-(1aalpha,2abeta,;ai3-17689[qr];caswellno663a[qr];cocculin[qr] |
Product Name: Picrotoxin
Synonyms: 3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione(1:1)[qr] ; 3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione,hex ; Ahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-(1ar-(1aalpha,2abeta),ai3)-17689[qr] ; Caswellno663a[qr] ; Cocculin[qr]
Product Categories: GABA/Glycine receptor
CAS NO: 124-87-8
Melting point: C30H34O13
Molecular Weight: 602.58
Molecular Structure:
EINECS: 204-716-6
Merck : 7415
Mol File: 124-87-8.mol
Flash Point: 228.9 °C
Enthalpy of Vaporization: 101.87 kJ/mol
Boiling Point: 595.8 °C at 760 mmHg
Vapour Pressure: 1.12E-16 mmHg at 25°C
Melting point: 203 °C(lit.)
Density 1,28 g/cm3
Solubility ethanol: 50 mg/mL, clear to slightly hazy
Appearance: Picrotoxin (CAS NO.124-87-8) is white to off-white powder or crystals.
1. | orl-hmn LDLo:357 µg/kg:CNS,GIT | 34ZIAG Toxicology of Drugs and Chemicals ,Deichmann, W.B.,New York, NY.: Academic Press, Inc.,1969,476. | ||
2. | ipr-rat LD50:1990 µg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 14 (1964),996. | ||
3. | scu-rat LD50:2880 µg/kg | JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. 38 (1949),604. | ||
4. | ivn-rat LD50:1600 µg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 14 (1964),996. | ||
5. | orl-mus LD50:15 mg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 128 (1960),176. | ||
6. | ipr-mus LD50:11 mg/kg | TXAPA9 Toxicology and Applied Pharmacology. 13 (1968),307. | ||
7. | scu-mus LD50:4100 µg/kg | RPOBAR Research Progress in Organic Biological and Medicinal Chemistry. 1 (1964),423. | ||
8. | ivn-mus LD50:2440 µg/kg | AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 135 (1962),9. | ||
9. | scu-dog LDLo:1500 µg/kg | HBAMAK “Abdernalden’s Handbuch der Biologischen Arbeitsmethoden.“ 4 (1935),1385. | ||
10. | ims-dog LD |
EPA Extremely Hazardous Substances List.
A human poison by ingestion. Poison experimentally by most routes. Human systemic effects by ingestion: somnolence, gastrointestinal effects. An alkaloid convulsant poison. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes T+T,N
Risk Statements 28-52/53
R28:Very toxic if swallowed.
R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements 28-36/37/39-45-61
S28:After contact with skin, wash immediately with plenty of soap-suds.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.
RIDADR UN 3462 6.1/PG 2
WGK Germany 3
RTECS TJ9100000
F 8-10
Hazard Note Very Toxic
HazardClass 6.1(a)
PackingGroup I
DOT Classification: 6.1; Label: Poison
1.General Description: A poisonous berry, the dried fruit of Anamirta Picrotoxinl. Contains several substances including about one percent picrotoxin. Pure picrotoxin occurs as shiny leaflets with an intensely bitter taste or as a microcrystalline powder. Very poisonous!. Used in medicine as a central nervous system stimulant and antidote for barbiturate poisoning. Not currently regarded as a useful therapeutic agent.
2.Reactivity Profile: Picrotoxin (CAS NO.124-87-8) contains picrotoxin, a molecular compound of picrotoxinin and picrotin. May react with strong oxidizing agents and with strong reducing agents.
3.Health Hazard : Picrotoxin (CAS NO.124-87-8) is highly toxic and a dose of 20 mg may produce symptoms of severe poisoning. A human lethal dose of 1.5 mg/kg has been reported. It is an alkaloid convulsant poison.
4.Fire Hazard: When heated to decomposition Picrotoxin emits acrid smoke and fumes. Avoid decomposing heat.