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| Name |
PROSCILLARIDIN |
EINECS | N/A |
| CAS No. | 466-06-8 | Density | 1.33g/cm3 |
| PSA | 129.59000 | LogP | 3.01380 |
| Solubility | N/A | Melting Point |
233°C |
| Formula | C30H42 O8 | Boiling Point | 716.7°Cat760mmHg |
| Molecular Weight | 530.659 | Flash Point | 232.6°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by ingestion, intravenous, and intraduodenal routes. When heated to decomposition it emits acrid smoke and irritating fumes. | Risk Codes | 25 |
| Molecular Structure |
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Hazard Symbols |
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| Synonyms |
ProscillaridinA (6CI,7CI,8CI); 14-Hydroxy-3b-(rhamnosyloxy)bufa-4,20,22-trienolide; 3b-Rhamnosido-14b-hydroxy-D4,20,22-bufatrienolide; 3b-[(6-Deoxy-a-L-mannopyranosyl)oxy]-14-hydroxybufa-4,20,22-trienolide;A 32686; Caradrin; Cardion; Cardiovite; Carmazon; Coratol;Desglucotransvaaline; Desglucotrnasvaaline; Herzo Proscillan; NSC 7521;PSC-801; Procardin; Procilan; Proscillan; Proscillaridin; Prostosin; Proszine;Protasin; Purosin-TC; Sandoscill; Scillacrist; Scillarenin 3b-rhamnoside; Simeon; Solestril;Stellarid; Talucard; Talusin; Tradenal; Transvaalin, degluco-; Urgilan;Wirnesin |
PROSCILLARIDIN Chemical Properties
IUPAC Name: 5-[(3S,8R,9S,10R,13R,14S,17R)-14-hydroxy-10,13-dimethyl-3-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy1,2,3,6,7,8,9,11,12,15,16,17-
dodecahydrocyclopenta[a]phenanthren-17-yl]pyran-2-one
Synonyms: Scillarenin 3beta-rhamnoside ; Proscillaridin ; Proscillaridin A; ((6-Deoxy-alpha-l-mannopyranosyl)oxy)-14-hydroxybufa-4,20,22-trienolide ; 14-Hydroxy-3-beta-(rhamnosyloxy)bufa-4,20,22-trienolide ; 22-Trienolide,3-((6-deoxy-alpha-l-mannopyranosyl)oxy)-14-hydroxy-bufa-20 ;22-Trienolide,3-beta-((6-deoxy-alpha-l-mannosyl)oxy)-14-hydroxy-bufa-20 ; 3-Beta-((6-deoxy-alpha-l-mannopyranosyl)oxy)-14-hydroxybufa-4,20,22-trienoli
CAS NO: 466-06-8
Molecular Formula: C30H42O8
Molecular Weight: 530.65
Molecular Structure:
EINECS: 207-370-4
Product Categories:
Mol File: 466-06-8.mol
Index of Refraction: 1.619
Surface Tension: 62.3 dyne/cm
Density: 1.33 g/cm3
Flash Point: 232.6 °C
Enthalpy of Vaporization: 119.66 kJ/mol
Boiling Point: 716.7 °C at 760 mmHg
Vapour Pressure: 1E-23 mmHg at 25°C
Melting point: 233°C
Storage temp: Keep Proscillaridin (CAS NO.466-06-8) at 2-8°C
PROSCILLARIDIN Uses
Proscillaridin (CAS NO.466-06-8) is clinically used as a tonic,mainly used for heart valve disease, ischemic heart disease and hypertensive heart disease
PROSCILLARIDIN Toxicity Data With Reference
| 1. | orl-rat LD50:56 mg/kg | TXAPA9 Toxicology and Applied Pharmacology. 20 (1971),599. | ||
| 2. | ivn-rat LD50:9 mg/kg | TXAPA9 Toxicology and Applied Pharmacology. 20 (1971),599. | ||
| 3. | orl-mus LD50:30,500 µg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),723. | ||
| 4. | ivn-mus LD50:23,200 µg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),723. | ||
| 5. | ivn-cat LD50:111 µg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 20 (1970),1. | ||
| 6. | idu-cat LDLo:268 µg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 14 (1964),716. | ||
| 7. | orl-gpg LD50:6810 µg/kg | USXXAM United States Patent Document. (Commissioner of Patents and Trademarks, Washington, DC 20231) #4230702 . | ||
| 8. | ivn-gpg LD50:280 µg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 20 (1970),1. |
PROSCILLARIDIN Safety Profile
Poison by ingestion, intravenous, and intraduodenal routes. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes 
T
Risk Statements 25
R25 : Proscillaridin (CAS NO.466-06-8) is toxic if swallowed.
Safety Statements 28-45
S28:After contact with skin, wash immediately with plenty of soap-suds.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS UK6650000
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