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Name	PROTOVERATRINE A	EINECS	205-602-9
CAS No.	143-57-7	Density	1.36 g/cm³
PSA	218.82000	LogP	1.54510
Solubility	N/A	Melting Point	267-269°C
Formula	C41H63 N O14	Boiling Point	810.6 °C at 760 mmHg
Molecular Weight	793.95	Flash Point	444 °C
Transport Information	UN 1544 6	Appearance	N/A
Safety	22-36/37/39-45	Risk Codes	26/27/28
Molecular Structure		Hazard Symbols	T+
Synonyms	Cevane-3,4,6,7,14,15,16,20-octol,4,9-epoxy-, 6,7-diacetate 3-(2-hydroxy-2-methylbutanoate)15-(2-methylbutanoate), [3b(S),4a,6a,7a,15a(R),16b]-; Cevane-3b,4b,6a,7a,14,15a,16b,20-octol, 4,9-epoxy-,6,7-diacetate 3-((+)-2-hydroxy-2-methylbutyrate) 15-((-)-2-methylbutyrate)(8CI); Protoverine, 6,7-diacetate 3-(2-hydroxy-2-methylbutyrate)15-(2-methylbutyrate) (6CI);2H-4,16a-Epoxybenzo[7,8]fluoreno[2,1-b]quinolizine,cevane-3,4,6,7,14,15,16,20-octol deriv.; NSC 23865; NSC 7526; Protalba;Protoveratrin; Protoveratrine; Protoveratrine A; Protoverine3-[(+)-(2S)-2-hydroxy-2-methylbutyrate] 6,7-diacetate15-[(-)-(2R)-2-methylbutyrate]

PROTOVERATRINE A Chemical Properties

MF: C₄₁H₆₃NO₁₄
MW: 793.94
EINECS: 205-602-9
PROTOVERATRINE A,it's melting point is about 267-269°C.
Following is the molecular structure about it:

PROTOVERATRINE A Uses

about Protoveratrine: Mixtures of closely related hypotensive alkaloids from Veratrum album (Liliaceae). They have been used in the treatment of hypertension but have largely been replaced by drugs with fewer adverse effects.

PROTOVERATRINE A Toxicity Data With Reference

RTECS FL5750100

1.	orl-rat LD50:5 mg/kg	AEPPAE Naunyn-Schmiedebergs Archiv fuer Experimentelle Pathologie und Pharmakologie. 189 (1938),397.
2.	scu-rat LD50:480 μg/kg	APFRAD Annales Pharmaceutiques Francaises. 14 (1956),783.
3.	ipr-mus LD50:370 μg/kg	PSEBAA Proceedings of the Society for Experimental Biology and Medicine. 76 (1951),847.
4.	scu-mus LD50:290 μg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 113 (1955),89.
5.	ivn-mus LD50:31 μg/kg	CKFRAY Ceskoslovenska Farmacie. 10 (1961),413.
6.	scu-dog LDLo:500 μg/kg	AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. 29 (1892),440.
7.	scu-cat LDLo:500 μg/kg	AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. 29 (1892),440.
8.	scu-rbt LDLo:250 μg/kg	APFRAD Annales Pharmaceutiques Francaises. 14 (1956),783.
9.	ivn-rbt LDLo:50 μg/kg	AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. 29 (1892),440.
10.	scu-frg LD50:4500 μg/kg	AEPPAE Naunyn-Schmiedebergs Archiv fuer Experimentelle Pathologie und Pharmakologie. 189

PROTOVERATRINE A Safety Profile

Safety Information about PROTOVERATRINE A:
Hazard Codes : T+
Risk Statements 26/27/28
Safety Statements 22-36/37/39-45
RIDADR UN 1544 6.1/PG 1

Poison by ingestion, subcutaneous, intraperitoneal, and intravenous routes. When heated to decomposition it emits toxic fumes of NO_x.
Protoveratrine is found to produce a striking fall in blood pressure in both essential and renal hypertension after intravenous administration.

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