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Pernazine

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Name

Pernazine

EINECS N/A
CAS No. 84-97-9 Density 1.149g/cm3
PSA 35.02000 LogP 3.86760
Solubility N/A Melting Point 51-53oC
Formula C20H25 N3 S Boiling Point 493.6°C at 760 mmHg
Molecular Weight 339.505 Flash Point 252.3°C
Transport Information N/A Appearance N/A
Safety Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. Human toxic effects by unspecified route. When heated to decomposition it emits very toxic fumes of NOx and SOx. Risk Codes N/A
Molecular Structure Molecular Structure of 84-97-9 (10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine) Hazard Symbols N/A
Synonyms

Phenothiazine,10-[3-(4-methyl-1-piperazinyl)propyl]- (6CI,7CI,8CI);10-(3-Methylpiperazinopropyl)phenothiazine; 10-(g-Methylpiperazinopropyl)phenothiazine;10-[3-(1-Methylpiperazin-4-yl)propyl]phenothiazine;10-[3-(4-Methyl-1-piperazinyl)propyl]phenothiazine;10-[3-(4-Methylpiperazinyl)propyl]phenothiazine; NSC 638694; P 725; Perazine;Pernazine; Psytomin; Taxilan

Article Data 15

Pernazine Chemical Properties

Chemistry informtion about Pernazine (CAS NO.84-97-9) is:
IUPAC Name: 10-[3-(4-Methylpiperazin-1-Yl)Propyl]Phenothiazine
Synonyms: 10-[3-(4-Methyl-1-Piperazinyl)Propyl]-10h-Phenothiazine ; Perazine ; 10-[3-[4-Methyl-1-Piperazinyl] Propyl] Phenothiazine ; 10h-Phenothiazine, 10-(3-(4-Methyl-1-Piperazinyl)Propyl)-, (Z)-2-Buten Edioate (1:2) ; 10-[3-(4-Methylpiperazinyl)Propyl]Phenothiazine ; Nsc 638694 ; P 725 ; Pernazine
Product Categories: Heterocyclic Compounds ; Heterocycles ; Intermediates & Fine Chemicals ; Pharmaceuticals ; Sulfur & Selenium Compounds 
MF: C20H25N3S
MW: 339.4976
EINECS: 201-578-9
Density: 1.149 g/cm3
Melting Point: 51-53°C 
Flash Point: 252.3 °C
Boiling Point: 493.6 °C at 760 mmHg
Vapour Pressure: 6.91E-10 mmHg at 25°C
Enthalpy of Vaporization: 76.08 kJ/mol
Following is the molecular structure of Pernazine (CAS NO.84-97-9) is:

Pernazine Uses

Pernazine (CAS NO.84-97-9) was used as Antipsychotic.

Pernazine Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo unreported 270mg/kg/28D (270mg/kg) behavioral: somnolence (general depressed activity) behavioral: ataxia Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 911, 1982.
mouse LD50 intraperitoneal 185mg/kg (185mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 199, 1958.
mouse LD50 intravenous 75mg/kg (75mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 199, 1958.
mouse LD50 oral 640mg/kg (640mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 199, 1958.
mouse LD50 subcutaneous 560mg/kg (560mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 199, 1958.
rabbit LD50 intravenous 25mg/kg (25mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 199, 1958.
rat LD50 intraperitoneal 300mg/kg (300mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 199, 1958.
rat LD50 intravenous 80mg/kg (80mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 199, 1958.
rat LD50 oral 500mg/kg (500mg/kg) behavioral: convulsions or effect on seizure threshold Archives Internationales de Pharmacodynamie et de Therapie. Vol. 115, Pg. 1, 1958.

Pernazine Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. Human toxic effects by unspecified route. When heated to decomposition it emits very toxic fumes of NOx and SOx.

Pernazine Specification

 Pernazine (CAS NO.84-97-9) is a crystalline solid.

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