- Phenformin
- Phenformin hydrochloride
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Cas Database |
| Name |
Phenformin |
EINECS | 204-057-4 |
| CAS No. | 114-86-3 | Density | 1.24 g/cm3 |
| PSA | 97.78000 | LogP | 2.72010 |
| Solubility | N/A | Melting Point |
280-282°C |
| Formula | C10H15N5 | Boiling Point | 413.7 °C at 760 mmHg |
| Molecular Weight | 205.263 | Flash Point | 204 °C |
| Transport Information | N/A | Appearance | white powder |
| Safety | 36 | Risk Codes | 22 |
| Molecular Structure |
|
Hazard Symbols |
 Xn
|
| Synonyms |
Biguanide,1-phenethyl- (6CI,8CI);(Phenylethyl)biguanide;1-Phenethylbiguanide;Cronoformin;Debeone;Diabis;Dibiraf;Dibotin;Fenfoduron;Fenformin;Fenormin;Glukopostin;Glyphen;Phenethylbiguanide; |
Article Data | 10 |
Phenformin Chemical Properties
Molecular Structure of Phenformin (CAS NO.114-86-3):
.png)
IUPAC Name: 1-(diaminomethylidene)-2-phenethylguanidine
Empirical Formula: C10H15N5
Molecular Weight: 205.2596
EINECS: 204-057-4
H bond acceptors: 5
H bond donors: 6
Freely Rotating Bonds: 4
Polar Surface Area: 34.44 Å2
Index of Refraction: 1.62
Molar Refractivity: 57.93 cm3
Molar Volume: 164.8 cm3
Surface Tension: 53.8 dyne/cm
Density: 1.24 g/cm3
Flash Point: 204 °C
Enthalpy of Vaporization: 66.65 kJ/mol
Boiling Point: 413.7 °C at 760 mmHg
Vapour Pressure: 4.71E-07 mmHg at 25°C
Classification Code: Drug / Therapeutic Agent; Hypoglycemic agents; Tumor data
InChI
InChI=1/C10H15N5/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H6,11,12,13,14,15)
Smiles
c1(CCNC(NC(N)=N)=N)ccccc1
Phenformin Production
It derived from phenylethylamine hydrochloride and dicyandiamide by heating at 142 °C, responsed by post-processing.
Phenformin Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LD50 | subcutaneous | 16mg/kg (16mg/kg) | Medicina Experimentalis. Vol. 8, Pg. 237, 1963. | |
| guinea pig | LDLo | intravenous | 30mg/kg (30mg/kg) | "Hemoperfusion: Kidney and Liver Support and Detoxification, Proceedings of the International Symposium, Haifa, 1979," Sideman, S., and T.M.S. Chang, eds., Multiple parts, New York, Hemisphere Pub. Corp., 1980-Vol. 1, Pg. 337, 1980. | |
| mouse | LD50 | intraperitoneal | 140mg/kg (140mg/kg) | Bollettino Chimico Farmaceutico. Vol. 97, Pg. 396, 1958. | |
| mouse | LD50 | oral | 450mg/kg (450mg/kg) | Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 42, Pg. 236, 1985. | |
| rat | LD50 | oral | 650mg/kg (650mg/kg) | Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 42, Pg. 236, 1985. |
Phenformin Safety Profile
Poison by intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx.Safety information of Phenformin (CAS NO.114-86-3):
Hazard Codes: 
Xn
Risk Statements: 22
R22:Harmful if swallowed.
Safety Statements: 36
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: DU2200000
Phenformin Specification
Phenformin , with CAS number of 114-86-3, can be called Phenethvdiguanide ; N′-β-Phenethylformamidin-ylliminourea ; N′-β-Fenetilformamidiniliminourea (italian) ; β-Phenethylbiguanide ; Phenformin Hydrochloride ; Phenformine [INN-French] ; Phenforminum [INN-Latin] ; Fenformina . Phenformin (CAS NO.114-86-3) is hypoglycemic agents, applicable to all types of diabetes. Can be made into a variety of products such as glass cloth laminated board, mold plastic film, adhesives, insulating paint, foam and fiber.
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