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Plafibride

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Name

Plafibride

EINECS N/A
CAS No. 63394-05-8 Density 1.251g/cm3
PSA 79.90000 LogP 2.33260
Solubility N/A Melting Point 100-102°
Formula C16H22 Cl N3 O4 Boiling Point N/A
Molecular Weight 355.821 Flash Point N/A
Transport Information N/A Appearance N/A
Safety Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. Experimental teratogenic and reproductive effects. Used as an antithrombotic agent. When heated to decomposition it emits very toxic fumes of Cl and NOx. Risk Codes N/A
Molecular Structure Molecular Structure of 63394-05-8 (plafibride) Hazard Symbols N/A
Synonyms

ITA 104;Idonor; Perifunal; Plafibride

Article Data 2

Plafibride Chemical Properties

Product Name: Plafibride (CAS NO.63394-05-8)


Molecular Formula: C16H22ClN3O4
Molecular Weight: 355.86g/mol
Mol File: 63394-05-8.mol
Einecs: 264-121-2
Density: 1.251 g/cm3
Surface Tension: 46.3 dyne/cm
XLogP3-AA: 2.4
H-Bond Donor: 2
H-Bond Acceptor: 5
Structure Descriptors of Plafibride (CAS NO.63394-05-8):
  IUPAC Name: 2-(4-chlorophenoxy)-2-methyl-N-(morpholin-4-ylmethylcarbamoyl)propanamide
  Canonical SMILES: CC(C)(C(=O)NC(=O)NCN1CCOCC1)OC2=CC=C(C=C2)Cl
  InChI: InChI=1S/C16H22ClN3O4/c1-16(2,24-13-5-3-12(17)4-6-13)14(21)19-15(22)18-11-20-7-9-23-10-8-20/h3-6H,7-11H2,1-2H3,(H2,18,19,21,22) 
  InChIKey: DDDQVDIPBFGVIG-UHFFFAOYSA-N

Plafibride Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 2168mg/kg (2168mg/kg)   Archivos de Farmacologia y Toxicologia. Vol. 4, Pg. 137, 1978.
hamster LD50 intraperitoneal 880mg/kg (880mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1816, 1981.
hamster LD50 oral > 4gm/kg (4000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1816, 1981.
mouse LD50 intraperitoneal 710mg/kg (710mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1816, 1981.
mouse LD50 intravenous 126mg/kg (126mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1816, 1981.
mouse LD50 oral 3365mg/kg (3365mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1816, 1981.
rat LD50 intraperitoneal 975mg/kg (975mg/kg)   Archivos de Farmacologia y Toxicologia. Vol. 4, Pg. 137, 1978.
rat LD50 intravenous 95mg/kg (95mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1816, 1981.
rat LD50 oral > 4gm/kg (4000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1816, 1981.

Plafibride Safety Profile

Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. Experimental teratogenic and reproductive effects. Used as an antithrombotic agent. When heated to decomposition it emits very toxic fumes of Cl and NOx.

Plafibride Specification

 Plafibride ,its CAS NO. is 63394-05-8,the synonyms is 1-(2-(p-Chlorophenoxy)-2-methylpropionyl)-3-(morpholinomethyl)urea ; BRN 0569805 ; EINECS 264-121-2 ; ITA-104 ; Idonor ; N'-Morpholinomethylurea, N-2-(p-chlorophenoxy)isobutyryl- ; N-2(p-Chlorophenoxy)-2-methylpropionyl-N'-morpholinomethylurea ; N-2(p-Chlorophenoxy)isobutyryl-N'-morpholinomethylurea ; Perifunal ; Plafibridum ; UNII-5J7C4JZ564 ; Propanamide, 2-(4-chlorophenoxy)-2-methyl-N-(((4-morpholinylmethyl)amino)carbonyl)- .

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