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105913-11-9
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Basic Information
CAS No.: 105913-11-9
Name: delta(2-89)-tissue plasminogen activator
Molecular Structure:
Molecular Structure of 105913-11-9 (delta(2-89)-tissue plasminogen activator)
Formula: N/A
Molecular Weight: 0
Synonyms: Angiokinase;GMK 527; K 2P; Plasminogen activator PLA; Pleurokinase; Tisokinase
Safety: A poison by subcutaneous and intravenous routes. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating vapors.
PSA: 0.00000
LogP: 0.00000
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    105913-11-9

    delta(2-89)-tissue plasminogen activator

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Chemistry

Product Name: Plasminogen activator
Synonyms of Plasminogen activator (CAS NO.105913-11-9): delta(2-89)-Tissue plasminogen activator ; AK-124 ; Angiokinase ; CCRIS 3520 ; GMK 527 ; Recombinant tissue-type plasminogen activator ; Tisokinase ; rt-PA ; Plasminogen activator ak-124
CAS NO: 105913-11-9
Classification Code: Reproductive Effect Mol File: 105913-11-9.mol

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
monkey LD50 intravenous > 3300ku/kg (3300000iu/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 33, Pg. 998, 1991.
mouse LD50 intravenous 51800ug/kg (51.8mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16(Suppl,
mouse LD50 subcutaneous > 100mg/kg (100mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16(Suppl,
rat LD50 intravenous 30400ug/kg (30.4mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16(Suppl,
rat LD50 subcutaneous > 60mg/kg (60mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16(Suppl,

Safety Profile

A poison by subcutaneous and intravenous routes. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating vapors.