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Basic Information
| CAS No.: | 1404-24-6 |
|---|---|
| Name: | Polymyxin A |
| Molecular Structure: | |
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| Formula: | N/A |
| Synonyms: | Polymixin A(7CI) |
| Safety: | Poison by intraperitoneal, subcutaneous, intravenous, and intracerebral routes. When heated to decomposition it emits acrid smoke and irritating fumes. |
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Polymyxin A
Chemistry
Product Name: Polymyxin A
CAS NO: 1404-24-6
Classification Codes : Drug / Therapeutic Agent
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | subcutaneous | 88mg/kg (88mg/kg) | "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 3, Pg. 1542, 1978. | |
| mouse | LDLo | intraperitoneal | 13mg/kg (13mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Lancet. Vol. 254, Pg. 127, 1948. |
| mouse | LDLo | intravenous | 6mg/kg (6mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Lancet. Vol. 254, Pg. 127, 1948. |
| rabbit | LDLo | intracrebral | 600ug/kg (0.6mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Annals of the New York Academy of Sciences. Vol. 51, Pg. 952, 1949. |
Safety Profile
Poison by intraperitoneal, subcutaneous, intravenous, and intracerebral routes. When Polymyxin A (CAS NO.1404-24-6) is heated to decomposition ,it emits acrid smoke and irritating fumes.