Diclazuril

Base Information Edit

Chemical Name:Diclazuril
CAS No.:101831-37-2
Molecular Formula:C₁₇H₉Cl₃N₄O₂
Molecular Weight:407.643
Hs Code.:29336990
European Community (EC) Number:640-372-7,692-717-6
NSC Number:759642
UNII:K110K1B1VE
DSSTox Substance ID:DTXSID4046787
Nikkaji Number:J413.493A
Wikipedia:Diclazuril
Wikidata:Q5273856
NCI Thesaurus Code:C76418
RXCUI:1368201
Metabolomics Workbench ID:152603
ChEMBL ID:CHEMBL284733
Mol file:101831-37-2.mol

Synonyms:2,6-dichloro-alpha-(4-chlorophenyl)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)benzeneacetonitrile;Clinacox;diclazuril;R 64433;R-64433

Suppliers and Price of Diclazuril

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Diclazuril
1mg
$ 991.00

Usbiological
Diclazuril
500ul
$ 523.00

Usbiological
Diclazuril
100mg
$ 403.00

TRC
Diclazuril
100mg
$ 85.00

TCI Chemical
Diclazuril >98.0%(HPLC)(T)
1g
$ 40.00

TCI Chemical
Diclazuril >98.0%(HPLC)(T)
5g
$ 198.00

Sigma-Aldrich
Diclazuril United States Pharmacopeia (USP) Reference Standard
200mg
$ 366.00

Sigma-Aldrich
Diclazuril for system suitability European Pharmacopoeia (EP) Reference Standard
y0000259
$ 190.00

Sigma-Aldrich
Diclazuril VETRANAL?, analytical standard
100 mg
$ 90.50

Sigma-Aldrich
Diclazuril VETRANAL
100mg-r
$ 87.70

Total 211 raw suppliers

Chemical Property of Diclazuril Edit

Chemical Property:

Appearance/Colour:Yellowish or white powder
Melting Point:548oC
Refractive Index:1.701
PKA:5.89±0.20(Predicted)
PSA：91.54000
Density:1.56 g/cm³
LogP:3.53648
Storage Temp.:0-6°C
XLogP3:4.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:405.979109
Heavy Atom Count:26
Complexity:629

Purity/Quality:

Above 99% ^*data from raw suppliers

Diclazuril ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1=CC(=CC=C1C(C#N)C2=C(C=C(C=C2Cl)N3C(=O)NC(=O)C=N3)Cl)Cl
Recent ClinicalTrials:Protocol For the Treatment of Cryptosporidiosis in AIDS Patients With Diclazuril (R64,433)
Description Diclazuril (molecular formula: C17H9Cl3N4O2, Trade name: Vecoxan) belongs to a kind of coccidiostat and potent antiprotozoal agents. It is mainly used for the treatment, control, prevention and improvements of Coccidal infections. It alleviates the symptoms of the patients by interrupting the life cycle of the parasites. It induces the morphological changes and attenuates the mitochondrial transmembrane potential in meroites. It can prevent congenital toxoplasmosis and have anticoccidial effects in vivo. It is active through oral administration.
Uses Diclazuril is a triazinone antiprotozoal that Nucleotide analog with broad-spectrum anticoccidial activity. It has a control effect on a variety of coccidiosis, and is used to prevent coccidiosis in chickens, ducks, quails, turkeys, geese and rabbits.

Technology Process of Diclazuril

There total 10 articles about Diclazuril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.64%