Phenylpiracetam hydrazide

Base Information Edit

Chemical Name:Phenylpiracetam hydrazide
CAS No.:77472-71-0
Molecular Formula:C12H15N3O2
Molecular Weight:233.27
Hs Code.:
UNII:289199VKN4
DSSTox Substance ID:DTXSID001032563
Wikipedia:Phenylpiracetam_hydrazide
Mol file:77472-71-0.mol

Synonyms:Phenylpiracetam hydrazide;77472-71-0;Fonturacetam hydrazide;1-Pyrrolidineacetic acid, 2-oxo-4-phenyl-, hydrazide;Phenylpiracetam hydrazide, (+/-)-;2-(2-oxo-4-phenylpyrrolidin-1-yl)acetohydrazide;289199VKN4;2-(2-oxo-4-phenyl-pyrrolidin-1-yl)acetohydrazide;UNII-289199VKN4;(R/S)-2-(2-Oxo-4-phenylpyrrolidin-1-yl)acetyl hydrazide;Oprea1_047789;Oprea1_738018;SCHEMBL20573309;WLZ3776;DTXSID001032563;BCP30571;AKOS024356209;2-[4-phenyl-2-oxopyrrolidin-1-yl]acetohydrazide;2-Oxo-4-phenylpyrrolidine-1-acetic acid hydrazide

Suppliers and Price of Phenylpiracetam hydrazide

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
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Total 36 raw suppliers

Chemical Property of Phenylpiracetam hydrazide Edit

Chemical Property:

Melting Point:154-155 °C
Boiling Point:529.4±50.0 °C(Predicted)
PSA：75.43000
Density:1.243±0.06 g/cm3(Predicted)
LogP:1.02150
XLogP3:-0.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:233.116426730
Heavy Atom Count:17
Complexity:300

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(CN(C1=O)CC(=O)NN)C2=CC=CC=C2
Uses 2-Oxo-4-phenylpyrrolidine-1-acetic acid hydrazide is mainly used as pharmaceutical intermediates.

Technology Process of Phenylpiracetam hydrazide

There total 4 articles about Phenylpiracetam hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 70291-40-6
2-oxo-4-phenyl-1-pyrrolidineacetic acid, ethyl ester

: 77472-71-0
2-Oxo-4-phenylpyrrolidine-1-acetic acid hydrazide

Guidance literature:: With hydrazine hydrate; at 0 - 20 ℃; for 20h;
DOI:10.1007/s11172-020-2861-0

Reference yield:

: 1198-97-6
4-phenylpyrrolidin-2-one

: 77472-71-0
2-Oxo-4-phenylpyrrolidine-1-acetic acid hydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) dioxane, 90 deg C, 1 h, 2.) 125 deg C, 5 h

2: 67 percent / hydrazine hydrate / ethanol / 8 h / Heating

With sodium hydride; hydrazine hydrate; In ethanol;
DOI:10.1007/BF00765621

Reference yield:

: 77519-55-2
2-oxo-4-phenylpyrrolidine-3-carboxylic acid

: 77472-71-0
2-Oxo-4-phenylpyrrolidine-1-acetic acid hydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: 58 percent / 0.5 h / 190 °C

2: 1.) NaH / 1.) dioxane, 90 deg C, 1 h, 2.) 125 deg C, 5 h

3: 67 percent / hydrazine hydrate / ethanol / 8 h / Heating

With sodium hydride; hydrazine hydrate; In ethanol;
DOI:10.1007/BF00765621

upstream raw materials:

2-oxo-4-phenyl-1-pyrrolidineacetic acid, ethyl ester

4-phenylpyrrolidin-2-one

2-oxo-4-phenylpyrrolidine-3-carboxylic acid

3-methoxycarbonyl-4-phenyl-2-pyrrolidone

Refernces Edit

1、 Glozman, O. M.,Morozov, I. S.,Zhmurenko, L. A.,Zagorevskii, V. A.. "THE SYNTHESIS AND ANTISPASMODIC ACTIVITY OF 4-PHENYLPYRROLIDONE-2-ACETAMIDES". . p. 776 - 780. Retrieved 2007/10/02.

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Technology Process of Phenylpiracetam hydrazide

Phenylpiracetam hydrazide

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